(4aR,7R,7aS)-methyl 7-((R)-2,2-difluoro-1-hydroxybut-3-en-1-yl)-6-(4-methoxybenzyl)-2,2,7a-trimethyl-5-oxooctahydro-[1,2]oxasilino[5,6-c]pyrrole-7-carboxylate

Base Information

Chemical Name:(4aR,7R,7aS)-methyl 7-((R)-2,2-difluoro-1-hydroxybut-3-en-1-yl)-6-(4-methoxybenzyl)-2,2,7a-trimethyl-5-oxooctahydro-[1,2]oxasilino[5,6-c]pyrrole-7-carboxylate
CAS No.:1367878-65-6
Molecular Formula:C₂₃H₃₁F₂NO₆Si
Molecular Weight:483.585
Hs Code.:

(4aR,7R,7aS)-methyl 7-((R)-2,2-difluoro-1-hydroxybut-3-en-1-yl)-6-(4-methoxybenzyl)-2,2,7a-trimethyl-5-oxooctahydro-[1,2]oxasilino[5,6-c]pyrrole-7-carboxylate

Synonyms:(4aR,7R,7aS)-methyl 7-((R)-2,2-difluoro-1-hydroxybut-3-en-1-yl)-6-(4-methoxybenzyl)-2,2,7a-trimethyl-5-oxooctahydro-[1,2]oxasilino[5,6-c]pyrrole-7-carboxylate

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Chemical Property of (4aR,7R,7aS)-methyl 7-((R)-2,2-difluoro-1-hydroxybut-3-en-1-yl)-6-(4-methoxybenzyl)-2,2,7a-trimethyl-5-oxooctahydro-[1,2]oxasilino[5,6-c]pyrrole-7-carboxylate

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Technology Process of (4aR,7R,7aS)-methyl 7-((R)-2,2-difluoro-1-hydroxybut-3-en-1-yl)-6-(4-methoxybenzyl)-2,2,7a-trimethyl-5-oxooctahydro-[1,2]oxasilino[5,6-c]pyrrole-7-carboxylate

There total 2 articles about (4aR,7R,7aS)-methyl 7-((R)-2,2-difluoro-1-hydroxybut-3-en-1-yl)-6-(4-methoxybenzyl)-2,2,7a-trimethyl-5-oxooctahydro-[1,2]oxasilino[5,6-c]pyrrole-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 704910-37-2
(3R,3aS,7aR)-3-Benzyloxymethyl-2-(4-methoxy-benzyl)-3a,5,5-trimethyl-1-oxo-octahydro-4-oxa-2-aza-5-sila-indene-3-carboxylic acid methyl ester

: 1367878-65-6
(4aR,7R,7aS)-methyl 7-((R)-2,2-difluoro-1-hydroxybut-3-en-1-yl)-6-(4-methoxybenzyl)-2,2,7a-trimethyl-5-oxooctahydro-[1,2]oxasilino[5,6-c]pyrrole-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 20 % Pd(OH)2/C; hydrogen / tetrahydrofuran

2: Dess-Martin periodane / dichloromethane / Inert atmosphere

3: n-butyllithium / tetrahydrofuran; diethyl ether; pentane / 1.5 h / Inert atmosphere; Cooling

With n-butyllithium; 20 % Pd(OH)2/C; hydrogen; Dess-Martin periodane; In tetrahydrofuran; diethyl ether; dichloromethane; pentane;
DOI:10.1016/j.jfluchem.2012.01.003

Reference yield:

: 704910-44-1
(3R,3aS,7aR)-3-Hydroxymethyl-2-(4-methoxy-benzyl)-3a,5,5-trimethyl-1-oxo-octahydro-4-oxa-2-aza-5-sila-indene-3-carboxylic acid methyl ester

: 1367878-65-6
(4aR,7R,7aS)-methyl 7-((R)-2,2-difluoro-1-hydroxybut-3-en-1-yl)-6-(4-methoxybenzyl)-2,2,7a-trimethyl-5-oxooctahydro-[1,2]oxasilino[5,6-c]pyrrole-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / Inert atmosphere

2: n-butyllithium / tetrahydrofuran; diethyl ether; pentane / 1.5 h / Inert atmosphere; Cooling

With n-butyllithium; Dess-Martin periodane; In tetrahydrofuran; diethyl ether; dichloromethane; pentane;
DOI:10.1016/j.jfluchem.2012.01.003

Reference yield: 85.0%

: 1367878-65-6
(4aR,7R,7aS)-methyl 7-((R)-2,2-difluoro-1-hydroxybut-3-en-1-yl)-6-(4-methoxybenzyl)-2,2,7a-trimethyl-5-oxooctahydro-[1,2]oxasilino[5,6-c]pyrrole-7-carboxylate

: 1367878-66-7
(2R,3S,4R)-methyl 2-((R)-2,2-difluoro-1-hydroxybut-3-en-1-yl)-3-hydroxy-4-(2-hydroxyethyl)-1-(4-methoxybenzyl)-3-methyl-5-oxopyrrolidine-2-carboxylate

Guidance literature:: With potassium fluoride; dihydrogen peroxide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; water; at 23 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.jfluchem.2012.01.003