<<1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(S)-hydroxy-(3aS,9aS)-1H-benzinden-5-yl>oxy>acetonitrile

Base Information

Chemical Name:<<1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(S)-hydroxy-(3aS,9aS)-1H-benzinden-5-yl>oxy>acetonitrile
CAS No.:101691-77-4
Molecular Formula:C₂₄H₃₃NO₂
Molecular Weight:367.532
Hs Code.:

<<1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(S)-hydroxy-(3aS,9aS)-1H-benz<f>inden-5-yl>oxy>acetonitrile

Synonyms:<<1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(S)-hydroxy-(3aS,9aS)-1H-benzinden-5-yl>oxy>acetonitrile

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Chemical Property of <<1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(S)-hydroxy-(3aS,9aS)-1H-benzinden-5-yl>oxy>acetonitrile

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Technology Process of <<1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(S)-hydroxy-(3aS,9aS)-1H-benzinden-5-yl>oxy>acetonitrile

There total 24 articles about <<1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(S)-hydroxy-(3aS,9aS)-1H-benzinden-5-yl>oxy>acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 107-14-2
chloroacetonitrile

: 101691-76-3,111137-56-5,111137-58-7
(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2H-benzinden-2,5-diol

: 101691-77-4,111186-51-7,111264-20-1
<<(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1H-benzinden-5-yl>oxy>acetonitrile

Guidance literature:: With potassium carbonate; In acetone; at 65 ℃; for 24h;
DOI:10.1021/jo00234a016

Reference yield: 89.0%

: 107-14-2
chloroacetonitrile

: 101691-76-3
1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-(3aS,9aS)-1H-benzindene-2(R),5-diol

: 101691-77-4
<<1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(S)-hydroxy-(3aS,9aS)-1H-benzinden-5-yl>oxy>acetonitrile

Guidance literature:: With potassium carbonate; In acetone; at 65 ℃; for 24h;
DOI:10.1021/jo00234a016

Reference yield:

: 4441-57-0
4-cyclohexylbutan-1-ol

: 101691-77-4
<<1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(S)-hydroxy-(3aS,9aS)-1H-benzinden-5-yl>oxy>acetonitrile

Guidance literature:: Multi-step reaction with 9 steps

1: 96 percent / phosphorus tribromide / 3.75 h / 0 - 100 °C

2: 81 percent / n-butyllithium / tetrahydrofuran; hexane / 5 h / 20 - 60 °C

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, -78 deg C to 0 deg C, 3 h

4: H₂ / 10percent Pd/C / ethanol / 46 h / 2585.7 Torr / Ambient temperature

5: 93 percent / aq. sodium hydride, sodium borohydride / ethanol; CH₂Cl₂ / 2 h / -10 °C

6: 40 percent / triethylamine / toluene / 0.42 h

7: 100 percent / lithium aluminium hydride / tetrahydrofuran / 4 h / 60 - 65 °C

8: 94.5 percent / diphenylphosphine, n-butyllithium / tetrahydrofuran; hexane / 25 h / 70 °C

9: 89 percent / K₂CO₃ / acetone / 24 h / 65 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; hydrogen; phosphorus tribromide; sodium hydride; potassium carbonate; triethylamine; diphenylphosphane; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetone; toluene;
DOI:10.1021/jo00234a016