1-<(1R,2S)-2-(2-fluorophenyl)-2,3-dihydroxy-1-methylpropyl>-3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2-imidazolidinone

Base Information

Chemical Name:1-<(1R,2S)-2-(2-fluorophenyl)-2,3-dihydroxy-1-methylpropyl>-3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2-imidazolidinone
CAS No.:174563-07-6
Molecular Formula:C₂₂H₂₃F₅N₂O₄
Molecular Weight:474.428
Hs Code.:

Synonyms:1-<(1R,2S)-2-(2-fluorophenyl)-2,3-dihydroxy-1-methylpropyl>-3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2-imidazolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<(1R,2S)-2-(2-fluorophenyl)-2,3-dihydroxy-1-methylpropyl>-3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2-imidazolidinone

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Technology Process of 1-<(1R,2S)-2-(2-fluorophenyl)-2,3-dihydroxy-1-methylpropyl>-3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2-imidazolidinone

There total 6 articles about 1-<(1R,2S)-2-(2-fluorophenyl)-2,3-dihydroxy-1-methylpropyl>-3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2-imidazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 174563-04-3
1-[(1R,2S)-2-(2-fluorophenyl)-2,3-dihydroxy-1-methylpropyl]-3-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-2(1H,3H)-imidazolone

: 174563-07-6
1-<(1R,2S)-2-(2-fluorophenyl)-2,3-dihydroxy-1-methylpropyl>-3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2-imidazolidinone

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; at 50 ℃; for 3h; under 760 Torr;
DOI:10.1248/cpb.47.360

Reference yield:

: 174951-49-6
(2S)-2'-fluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propiophenone

: 174563-07-6
1-<(1R,2S)-2-(2-fluorophenyl)-2,3-dihydroxy-1-methylpropyl>-3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2-imidazolidinone

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / pyridinium p-toluenesulfonate / ethanol / 2.5 h / 55 °C

2: 88 percent / i-Pr₂NEt / CH₂Cl₂ / 0.5 h / -30 °C

3: 1.) NaH, 1-methyl-2-pyrrolidone / 1.) RT, 15 min, 2.) THF, -20 deg C, 10 min

4: 1.) Mg, MeI / 1.) THF, from 45 deg C to 50 deg C, 3 h, 2.) THF, 0 deg C, 20 min

5: 89 percent / 30 percent aq. H₂O₂, NaHCO₃ / methanol; tetrahydrofuran / 1.5 h / 70 - 80 °C

6: 20 percent / H₂, AcOH / 10 percent Pd/C / 3 h / 50 °C / 760 Torr

With 1-methyl-pyrrolidin-2-one; hydrogen; dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydride; sodium hydrogencarbonate; magnesium; acetic acid; N-ethyl-N,N-diisopropylamine; methyl iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1248/cpb.47.360

Reference yield:

: 174563-15-6
(S)-1-(2-Fluorophenyl)-2-hydroxypropanone

: 174563-07-6
1-<(1R,2S)-2-(2-fluorophenyl)-2,3-dihydroxy-1-methylpropyl>-3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2-imidazolidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / i-Pr₂NEt / CH₂Cl₂ / 0.5 h / -30 °C

2: 1.) NaH, 1-methyl-2-pyrrolidone / 1.) RT, 15 min, 2.) THF, -20 deg C, 10 min

3: 1.) Mg, MeI / 1.) THF, from 45 deg C to 50 deg C, 3 h, 2.) THF, 0 deg C, 20 min

4: 89 percent / 30 percent aq. H₂O₂, NaHCO₃ / methanol; tetrahydrofuran / 1.5 h / 70 - 80 °C

5: 20 percent / H₂, AcOH / 10 percent Pd/C / 3 h / 50 °C / 760 Torr

With 1-methyl-pyrrolidin-2-one; hydrogen; dihydrogen peroxide; sodium hydride; sodium hydrogencarbonate; magnesium; acetic acid; N-ethyl-N,N-diisopropylamine; methyl iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1248/cpb.47.360