Technology Process of 1-<(1R,2S)-2-(2-fluorophenyl)-2,3-dihydroxy-1-methylpropyl>-3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2-imidazolidinone
There total 6 articles about 1-<(1R,2S)-2-(2-fluorophenyl)-2,3-dihydroxy-1-methylpropyl>-3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2-imidazolidinone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen; acetic acid;
palladium on activated charcoal;
at 50 ℃;
for 3h;
under 760 Torr;
DOI:10.1248/cpb.47.360
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 97 percent / pyridinium p-toluenesulfonate / ethanol / 2.5 h / 55 °C
2: 88 percent / i-Pr2NEt / CH2Cl2 / 0.5 h / -30 °C
3: 1.) NaH, 1-methyl-2-pyrrolidone / 1.) RT, 15 min, 2.) THF, -20 deg C, 10 min
4: 1.) Mg, MeI / 1.) THF, from 45 deg C to 50 deg C, 3 h, 2.) THF, 0 deg C, 20 min
5: 89 percent / 30 percent aq. H2O2, NaHCO3 / methanol; tetrahydrofuran / 1.5 h / 70 - 80 °C
6: 20 percent / H2, AcOH / 10 percent Pd/C / 3 h / 50 °C / 760 Torr
With
1-methyl-pyrrolidin-2-one; hydrogen; dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydride; sodium hydrogencarbonate; magnesium; acetic acid; N-ethyl-N,N-diisopropylamine; methyl iodide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1248/cpb.47.360
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 88 percent / i-Pr2NEt / CH2Cl2 / 0.5 h / -30 °C
2: 1.) NaH, 1-methyl-2-pyrrolidone / 1.) RT, 15 min, 2.) THF, -20 deg C, 10 min
3: 1.) Mg, MeI / 1.) THF, from 45 deg C to 50 deg C, 3 h, 2.) THF, 0 deg C, 20 min
4: 89 percent / 30 percent aq. H2O2, NaHCO3 / methanol; tetrahydrofuran / 1.5 h / 70 - 80 °C
5: 20 percent / H2, AcOH / 10 percent Pd/C / 3 h / 50 °C / 760 Torr
With
1-methyl-pyrrolidin-2-one; hydrogen; dihydrogen peroxide; sodium hydride; sodium hydrogencarbonate; magnesium; acetic acid; N-ethyl-N,N-diisopropylamine; methyl iodide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1248/cpb.47.360
![1-[(1R,2S)-2-(2-fluorophenyl)-2,3-dihydroxy-1-methylpropyl]-3-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-2(1H,3H)-imidazolone](/Databaselist/images/loading.webp)
