(S)-1-tert-butyl 3-((R)-1-phenylethyl) 2-methyl-2-(4-fluorobenzyl)malonate

Base Information

Chemical Name:(S)-1-tert-butyl 3-((R)-1-phenylethyl) 2-methyl-2-(4-fluorobenzyl)malonate
CAS No.:1440524-67-3
Molecular Formula:C₂₃H₂₇FO₄
Molecular Weight:386.463
Hs Code.:

Synonyms:(S)-1-tert-butyl 3-((R)-1-phenylethyl) 2-methyl-2-(4-fluorobenzyl)malonate

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Chemical Property of (S)-1-tert-butyl 3-((R)-1-phenylethyl) 2-methyl-2-(4-fluorobenzyl)malonate

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Technology Process of (S)-1-tert-butyl 3-((R)-1-phenylethyl) 2-methyl-2-(4-fluorobenzyl)malonate

There total 2 articles about (S)-1-tert-butyl 3-((R)-1-phenylethyl) 2-methyl-2-(4-fluorobenzyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1440524-44-6
1-tert-butyl 3-((R)-1-phenylethyl) 2-methylmalonate

: 459-46-1
4-Fluorobenzyl bromide

: 1440524-67-3
(S)-1-tert-butyl 3-((R)-1-phenylethyl) 2-methyl-2-(4-fluorobenzyl)malonate

Guidance literature:: With (11bS,11b’S)-2,6-bis(3,4,5-trifluorophenyl)-3,3’,5,5’-tetrahydro-4,4’-spirobi[dinaphtho[2,1-c:1’,2’-e]azepin]-4-ium bromide; potassium hydroxide; In water; toluene; at -40 ℃; for 168h; stereoselective reaction;
DOI:10.1039/c3ob40481a

Reference yield:

: 37472-52-9
α-methylmalonate mono-tert-butyl ester

: 1440524-67-3
(S)-1-tert-butyl 3-((R)-1-phenylethyl) 2-methyl-2-(4-fluorobenzyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 15 h / Inert atmosphere

2: potassium hydroxide; (11bS,11b’S)-2,6-bis(3,4,5-trifluorophenyl)-3,3’,5,5’-tetrahydro-4,4’-spirobi[dinaphtho[2,1-c:1’,2’-e]azepin]-4-ium bromide / toluene; water / 168 h / -40 °C

With dmap; (11bS,11b’S)-2,6-bis(3,4,5-trifluorophenyl)-3,3’,5,5’-tetrahydro-4,4’-spirobi[dinaphtho[2,1-c:1’,2’-e]azepin]-4-ium bromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In dichloromethane; water; toluene;
DOI:10.1039/c3ob40481a