Propanedioic acid, methyl-, mono(1,1-dimethylethyl) ester

Base Information

• Chemical Name: Propanedioic acid, methyl-, mono(1,1-dimethylethyl) ester
• CAS No.: 37472-52-9
• Molecular Formula: C8H14O4
• Molecular Weight: 174.197
• Mol file: 37472-52-9.mol

Synonyms:Methylmalonsaeure-tert.-butylester;2-Methyl-malonic acid mono-tert-butyl ester;methylmalonic acid mono-tert-butyl ester;

Chemical Property of Propanedioic acid, methyl-, mono(1,1-dimethylethyl) ester

Chemical Property:

• PSA: 63.60000
• LogP: 1.04880

Purity/Quality:

99% ^*data from raw suppliers

3-(tert-Butoxy)-2-methyl-3-oxopropanoicacid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanedioic acid, methyl-, mono(1,1-dimethylethyl) ester

There total 5 articles about Propanedioic acid, methyl-, mono(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,2,5-trimethyl-1,3-dioxane-4,6-dione (3709-18-0) + tert-butyl alcohol (75-65-0) → α-methylmalonate mono-tert-butyl ester (37472-52-9)

Guidance literature:

for 12h; Reflux;

DOI:10.1002/adsc.201500560

Reference yield: 37.0%

methyl-propanedioic acid (516-05-2) + tert-butyl alcohol (75-65-0) → α-methylmalonate mono-tert-butyl ester (37472-52-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In acetonitrile; at -15 - 25 ℃; for 14h;

DOI:10.3762/bjoc.17.135

Reference yield:

tert-butyl 2-oxybutanoate (37472-51-8) → α-methylmalonate mono-tert-butyl ester (37472-52-9)

Guidance literature:

With sodium periodate;

DOI:10.1021/ja00766a036

upstream raw materials:

tert-butyl 2-oxybutanoate

2,2,5-trimethyl-1,3-dioxane-4,6-dione

tert-butyl alcohol

methyl-propanedioic acid

Downstream raw materials:

(S)-α-benzyl-α-methylmalonic acid diphenylmethyl ester tert-butyl ester

(S)-2-benzyl-3-(tert-butoxy)-2-methyl-3-oxopropanoic acid

C₁₅H₂₁NO₃

methylmalonic acid benzyl tert-butyl ester

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