(3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-1,3-diphenylhex-1-yn-3-yl acetate

Base Information

• Chemical Name: (3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-1,3-diphenylhex-1-yn-3-yl acetate
• CAS No.: 1427519-87-6
• Molecular Formula: C₃₀H₃₁NO₄S
• Molecular Weight: 501.646
• Mol file: 1427519-87-6.mol

Synonyms:(3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-1,3-diphenylhex-1-yn-3-yl acetate

Chemical Property of (3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-1,3-diphenylhex-1-yn-3-yl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-1,3-diphenylhex-1-yn-3-yl acetate

There total 1 articles about (3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-1,3-diphenylhex-1-yn-3-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C27H27NO4S + allyl bromide (106-95-6) → (3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-1,3-diphenylhex-1-yn-3-yl acetate (1427519-87-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo400121j

Reference yield: 97.0%

(3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-1,3-diphenylhex-1-yn-3-yl acetate (1427519-87-6) → ((3R,6S)-6-ethyl-3-methyl-5-phenyl-1-tosyl-1,2,3,6-tetrahydropyridin-4-yl)(phenyl)methanone (1427520-25-9) + acetic acid (64-19-7,77671-22-8)

Guidance literature:

With Echavarren's catalyst; water; In 1,2-dichloro-ethane; at 80 ℃; for 24h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/jo400121j

Reference yield: 61.0%

(3S,4S)-4-(N-allyl-4-methylphenylsulfonamido)-1,3-diphenylhex-1-yn-3-yl acetate (1427519-87-6) → 1-((3R,6S)-4-benzoyl-6-ethyl-5-phenyl-1-tosyl-1,2,3,6-tetrahydropyridin-3-yl)propan-2-one (1427520-06-6)

Guidance literature:

With 1,3‐bis[2,6‐bis(propan‐2‐yl)phenyl]‐2‐[(phenylformonitrile)aurio]‐2,3‐dihydro‐1H‐imidazol‐2‐yl hexafluorostibane; In 1,2-dichloro-ethane; at 80 ℃; for 24h; stereoselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1021/jo400121j

upstream raw materials:

allyl bromide

Downstream raw materials:

((3R,6S)-6-ethyl-3-methyl-5-phenyl-1-tosyl-1,2,3,6-tetrahydropyridin-4-yl)(phenyl)methanone

acetic acid

1-((3R,6S)-4-benzoyl-6-ethyl-5-phenyl-1-tosyl-1,2,3,6-tetrahydropyridin-3-yl)propan-2-one