Technology Process of tetrabenzyl 3-oxo-3-[2-(3,4-dibenzyloxyphenyl)ethylamino]propane-1,1-bisphosphonate
There total 3 articles about tetrabenzyl 3-oxo-3-[2-(3,4-dibenzyloxyphenyl)ethylamino]propane-1,1-bisphosphonate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3,3-bis(dibenzyloxyphosphoryl)propanoic acid;
With
4-methyl-morpholine; isobutyl chloroformate;
In
tetrahydrofuran;
at -8 ℃;
for 0.333333h;
3,4-di(benzyloxy)phenethylamine;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
DOI:10.1002/hc.20013
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: NaH / tetrahydrofuran
2.1: CF3COOH / CH2Cl2
3.1: N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / -8 °C
3.2: 70.1 percent / tetrahydrofuran / 0.5 h / 20 °C
With
4-methyl-morpholine; sodium hydride; trifluoroacetic acid; isobutyl chloroformate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1002/hc.20013
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: CF3COOH / CH2Cl2
2.1: N-methylmorpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / -8 °C
2.2: 70.1 percent / tetrahydrofuran / 0.5 h / 20 °C
With
4-methyl-morpholine; trifluoroacetic acid; isobutyl chloroformate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1002/hc.20013