2,3-bis[4-(benzyloxy)phenyl]acrylonitrile

Base Information

• Chemical Name: 2,3-bis[4-(benzyloxy)phenyl]acrylonitrile
• CAS No.: 1418216-86-0
• Molecular Formula: C₂₉H₂₃NO₂
• Molecular Weight: 417.507
• Mol file: 1418216-86-0.mol

Synonyms:2,3-bis[4-(benzyloxy)phenyl]acrylonitrile

Chemical Property of 2,3-bis[4-(benzyloxy)phenyl]acrylonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-bis[4-(benzyloxy)phenyl]acrylonitrile

There total 1 articles about 2,3-bis[4-(benzyloxy)phenyl]acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

p-benzyloxybenzaldehyde (4397-53-9) + 2-[4-(benzyloxy)phenyl]acetonitrile (838-96-0) → 2,3-bis[4-(benzyloxy)phenyl]acrylonitrile (1418216-86-0)

Guidance literature:

With sodium methylate; In methanol; Inert atmosphere; Reflux;

DOI:10.3184/174751917X15105690662863

Reference yield: 95.0%

potassium cyanide + 2,3-bis[4-(benzyloxy)phenyl]acrylonitrile (1418216-86-0) → 2,3-bis[4-(benzyloxy)phenyl]succinonitrile (1418216-87-1)

Guidance literature:

With ammonium chloride; In water; N,N-dimethyl-formamide; at 20 - 100 ℃;

DOI:10.1055/s-0032-1317351

Reference yield:

2,3-bis[4-(benzyloxy)phenyl]acrylonitrile (1418216-86-0) → methyl 3,4-bis(4-(benzyloxy)phenyl)-1H-pyrrole-2-carboxylate (1418216-90-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ammonium chloride / water; N,N-dimethyl-formamide / 20 - 100 °C

2.1: diisobutylaluminium hydride / benzene; toluene / 20 °C

3.1: dmap / tetrahydrofuran / 0 - 25 °C

3.2: 24 h / 25 °C

With dmap; diisobutylaluminium hydride; ammonium chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1055/s-0032-1317351

upstream raw materials:

p-benzyloxybenzaldehyde

2-[4-(benzyloxy)phenyl]acetonitrile

Downstream raw materials:

2,3-bis[4-(benzyloxy)phenyl]succinonitrile

methyl 3,4-bis(4-(benzyloxy)phenyl)-1H-pyrrole-2-carboxylate

methyl 3,4-bis(4-benzyloxyphenyl)-1-<2-(4-methoxyphenyl)-2-oxoethyl>pyrrole-2-carboxylate

methyl 3,4-bis(4-hydroxyphenyl)-1H-pyrrole-2-carboxylate