methyl 3,4-bis(4-(benzyloxy)phenyl)-1H-pyrrole-2-carboxylate

Base Information

• Chemical Name: methyl 3,4-bis(4-(benzyloxy)phenyl)-1H-pyrrole-2-carboxylate
• CAS No.: 1418216-90-6
• Molecular Formula: C₃₂H₂₇NO₄
• Molecular Weight: 489.571
• Mol file: 1418216-90-6.mol

Synonyms:methyl 3,4-bis(4-(benzyloxy)phenyl)-1H-pyrrole-2-carboxylate

Chemical Property of methyl 3,4-bis(4-(benzyloxy)phenyl)-1H-pyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl 3,4-bis(4-(benzyloxy)phenyl)-1H-pyrrole-2-carboxylate

There total 9 articles about methyl 3,4-bis(4-(benzyloxy)phenyl)-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

isocyanoacetic acid methyl ester (39687-95-1) + 4,4'-(1-nitroethene-1,2-diyl)bis((4-(benzyloxy)benzene)) → methyl 3,4-bis(4-(benzyloxy)phenyl)-1H-pyrrole-2-carboxylate (1418216-90-6)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 12h;

DOI:10.1039/d0ra09249e

Reference yield: 70.0%

methanol (67-56-1) + 3,4-bis[4-(benzyloxy)phenyl]-1H-pyrrole (1418216-89-3) + trifluoroacetyl chloride (76-02-8) → methyl 3,4-bis(4-(benzyloxy)phenyl)-1H-pyrrole-2-carboxylate (1418216-90-6)

Guidance literature:

3,4-bis[4-(benzyloxy)phenyl]-1H-pyrrole; trifluoroacetyl chloride; With dmap; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

In tetrahydrofuran; Sonication;

methanol; With sodium methylate; In tetrahydrofuran; for 0.5h; Sonication;

DOI:10.3184/174751917X15105690662863

Reference yield: 53.0%

3,4-bis[4-(benzyloxy)phenyl]-1H-pyrrole (1418216-89-3) + sodium methylate (124-41-4) + trichloromethyl chloroformate (503-38-8) → methyl 3,4-bis(4-(benzyloxy)phenyl)-1H-pyrrole-2-carboxylate (1418216-90-6)

Guidance literature:

3,4-bis[4-(benzyloxy)phenyl]-1H-pyrrole; trichloromethyl chloroformate; With dmap; In tetrahydrofuran; at 0 - 25 ℃;

sodium methylate; In tetrahydrofuran; methanol; at 25 ℃; for 24h;

DOI:10.1055/s-0032-1317351

upstream raw materials:

3,4-bis[4-(benzyloxy)phenyl]-1H-pyrrole

sodium methylate

trichloromethyl chloroformate

2,3-bis[4-(benzyloxy)phenyl]succinonitrile

Downstream raw materials:

methyl 3,4-bis(4-benzyloxyphenyl)-1-<2-(4-methoxyphenyl)-2-oxoethyl>pyrrole-2-carboxylate

methyl 3,4-bis(4-hydroxyphenyl)-1H-pyrrole-2-carboxylate