2-Hydroxyethylazanium;chloride

Base Information

• Chemical Name: 2-Hydroxyethylazanium;chloride
• CAS No.: 2002-24-6
• Molecular Formula: C2H7NO•ClH
• Molecular Weight: 97.5446
• Hs Code.: 2923900090
• Mol file: 2002-24-6.mol

Synonyms:AKOS030228756

Chemical Property of 2-Hydroxyethylazanium;chloride

Chemical Property:

• Appearance/Colour: White or slightly beige agglomerating crystals
• Vapor Pressure: 0.458mmHg at 25°C
• Melting Point: 82-84oC(lit.)
• Boiling Point: 170.9°C at 760 mmHg
• PKA: 9.5(at 25℃)
• Flash Point: 93.3°C
• PSA: 46.25000
• LogP: 0.43970
• Storage Temp.: Store at RT.
• Sensitive.: Hygroscopic
• Solubility.: DMSO (Slightly, Heated)
• Water Solubility.: almost transparency
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 97.0294416
• Heavy Atom Count: 5
• Complexity: 10

Purity/Quality:

98% ^*data from raw suppliers

2-Aminoethanol Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(CO)[NH3+].[Cl-]
• Uses: Ethanolamine hydrochloride has been used:in overnight incubation of the tips to attach primary amine groups at the tip surfacein the preparation of DMEM (dulbecco′s modified eagle′s medium)/F-12 media to culture human epidermal growth factor receptor 2 (HER2) cells derived from MMTV-HER2 transgenic mouse mammary tumorsto administer the cultures to study its effect on the endogenous phosphatidyl ethanolamine pool and autophagy process

Technology Process of 2-Hydroxyethylazanium;chloride

There total 7 articles about 2-Hydroxyethylazanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanolamine (141-43-5) → 2-amino-ethanol hydrochloride (2002-24-6)

Guidance literature:

With hydrogenchloride; for 6h;

Reference yield: 85.0%

2-nitro-1-ethanol (625-48-9) → 2-amino-ethanol hydrochloride (2002-24-6)

Guidance literature:

2-nitro-1-ethanol; With C₃₆H₅₆Cl₃CrN₂O; magnesium; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; at 60 ℃; for 24h; Inert atmosphere; Schlenk technique;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate; at 20 ℃;

DOI:10.1021/jacs.0c12318

Reference yield: 68.8%

→ 2-amino-ethanol hydrochloride (2002-24-6)

Guidance literature:

upstream raw materials:

ethanolamine

1-(thien-2-yl)-3,4,4-trichloro-3-buten-1-one

1-(4-hydroxyphenyl)-3,4,4-trichloro-3-buten-1-one

ethyl 2,2,2-trichloroacetimidate

Downstream raw materials:

<2-Hydroxy-ethyl>-<5-methyl-furfuryl-(2)>-amin

N-(2-methylphenyl)ethylenediamine

1-methyl-piperazine

N-methyl-ethane-1,2-diamine

Refernces

• 1、 Sun, Jian,Konda, N. V. S. N. Murthy,Parthasarathi, Ramakrishnan,Dutta, Tanmoy,Valiev, Marat,Xu, Feng,Simmons, Blake A.,Singh, Seema. "One-pot integrated biofuel production using low-cost biocompatible protic ionic liquids". . p. 3152 - 3163. Retrieved 2017.
• 2、 Mou, Xue-Qing,Chen, Xiang-Yu,Chen, Gong,He, Gang. "Radical-mediated intramolecular β-C(sp3)-H amidation of alkylimidates: Facile synthesis of 1,2-amino alcohols". supporting information. p. 515 - 518. Retrieved 2018/01/19.