Technology Process of N-methyl-3a-(4-methoxyphenyl)-6β-acetoxy-cis-octahydroindol-2-one
There total 10 articles about N-methyl-3a-(4-methoxyphenyl)-6β-acetoxy-cis-octahydroindol-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) Mg / 1.) THF, reflux, 2.) reflux, 4 h
2: p-toluenesulfonic acid / benzene / 0.5 h / Heating
3: p-toluenesulfonic acid / methanol / 24 h / Ambient temperature
4: Zn / diethyl ether / 0.5 h / Heating
5: Zn, NH4Cl / methanol / 3 h / Heating
6: molecular sieves 3A, pyridine / 72 h / Ambient temperature
7: 1.) p-toluenesulfonyl chloride, 2.) H2O / 1.) pyridine, 0 deg C, 15 h, 2.) overnight
With
pyridine; 3 A molecular sieve; water; ammonium chloride; toluene-4-sulfonic acid; magnesium; p-toluenesulfonyl chloride; zinc;
In
methanol; diethyl ether; benzene;
DOI:10.1021/jo00141a015
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Zn / diethyl ether / 0.5 h / Heating
2: Zn, NH4Cl / methanol / 3 h / Heating
3: molecular sieves 3A, pyridine / 72 h / Ambient temperature
4: 1.) p-toluenesulfonyl chloride, 2.) H2O / 1.) pyridine, 0 deg C, 15 h, 2.) overnight
With
pyridine; 3 A molecular sieve; water; ammonium chloride; p-toluenesulfonyl chloride; zinc;
In
methanol; diethyl ether;
DOI:10.1021/jo00141a015
- Guidance literature:
-
Multi-step reaction with 8 steps
1: p-toluenesulfonic acid / 0.67 h / Ambient temperature
2: 1.) Mg / 1.) THF, reflux, 2.) reflux, 4 h
3: p-toluenesulfonic acid / benzene / 0.5 h / Heating
4: p-toluenesulfonic acid / methanol / 24 h / Ambient temperature
5: Zn / diethyl ether / 0.5 h / Heating
6: Zn, NH4Cl / methanol / 3 h / Heating
7: molecular sieves 3A, pyridine / 72 h / Ambient temperature
8: 1.) p-toluenesulfonyl chloride, 2.) H2O / 1.) pyridine, 0 deg C, 15 h, 2.) overnight
With
pyridine; 3 A molecular sieve; water; ammonium chloride; toluene-4-sulfonic acid; magnesium; p-toluenesulfonyl chloride; zinc;
In
methanol; diethyl ether; benzene;
DOI:10.1021/jo00141a015
