Technology Process of (3aR,9bS,αR)-N(1)-(4'-methoxy-α-methylbenzyl)-5-(tert-butoxycarbonyl)-8-bromo-2,3,3a,4,5,9bhexahydro-1H-pyrrolo[3,2-c]quinolin-2,4-dione
There total 8 articles about (3aR,9bS,αR)-N(1)-(4'-methoxy-α-methylbenzyl)-5-(tert-butoxycarbonyl)-8-bromo-2,3,3a,4,5,9bhexahydro-1H-pyrrolo[3,2-c]quinolin-2,4-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C37H51BrN2O5;
With
tetrakis(triphenylphosphine) palladium(0); 1,3-dimethylbarbituric acid;
In
dichloromethane;
at 35 ℃;
for 16h;
With
benzoic acid;
In
toluene;
for 16h;
Reflux;
di-tert-butyl dicarbonate;
With
dmap;
In
dichloromethane;
at 35 ℃;
for 16h;
DOI:10.1016/j.tet.2013.09.013
- Guidance literature:
-
With
dmap; triethylamine;
In
dichloromethane;
at 35 ℃;
for 16h;
DOI:10.1021/ol4007508
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: palladium diacetate; tri-o-tolylphosphine; triethylamine / acetonitrile / 16 h / 70 °C
2.1: potassium phosphate / acetone / 48 h / Reflux
3.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C
3.2: 2 h / -78 °C
4.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1 h / -78 °C
4.2: 17 h / -78 - 20 °C
5.1: tetrakis(triphenylphosphine) palladium(0); 1,3-dimethylbarbituric acid / dichloromethane / 32 h / 35 °C
6.1: benzoic acid / toluene / 16 h / Reflux
7.1: triethylamine; dmap / dichloromethane / 16 h / 35 °C
With
dmap; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; 1,3-dimethylbarbituric acid; tri-o-tolylphosphine; palladium diacetate; triethylamine; benzoic acid; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane; acetone; toluene; acetonitrile;
1.1: |Heck Reaction;
DOI:10.1021/ol4007508
