(-)-(3aR,6S,7aS,1'R)-3a,6-Epoxyperhydro-2-(2'-hydroxy-1'-phenylethyl)-7,7-dimethyl-1H-isoindol-1-on

Base Information

Chemical Name:(-)-(3aR,6S,7aS,1'R)-3a,6-Epoxyperhydro-2-(2'-hydroxy-1'-phenylethyl)-7,7-dimethyl-1H-isoindol-1-on
CAS No.:77704-41-7
Molecular Formula:C₁₈H₂₃NO₃
Molecular Weight:301.386
Hs Code.:

Synonyms:(-)-(3aR,6S,7aS,1'R)-3a,6-Epoxyperhydro-2-(2'-hydroxy-1'-phenylethyl)-7,7-dimethyl-1H-isoindol-1-on

Suppliers and Price of (-)-(3aR,6S,7aS,1'R)-3a,6-Epoxyperhydro-2-(2'-hydroxy-1'-phenylethyl)-7,7-dimethyl-1H-isoindol-1-on

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-(3aR,6S,7aS,1'R)-3a,6-Epoxyperhydro-2-(2'-hydroxy-1'-phenylethyl)-7,7-dimethyl-1H-isoindol-1-on

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-(3aR,6S,7aS,1'R)-3a,6-Epoxyperhydro-2-(2'-hydroxy-1'-phenylethyl)-7,7-dimethyl-1H-isoindol-1-on

There total 8 articles about (-)-(3aR,6S,7aS,1'R)-3a,6-Epoxyperhydro-2-(2'-hydroxy-1'-phenylethyl)-7,7-dimethyl-1H-isoindol-1-on which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 77704-39-3
(-)-(1R,5S,7S)-3-[(1R)-2-hydroxy-1-phenylethyl]-6,6-dimethyl-10-oxa-3-azatricyclo[5.2.1.0^1,5]dec-8-en-4-one

: 77704-41-7
(-)-(3aR,6S,7aS,1'R)-3a,6-Epoxyperhydro-2-(2'-hydroxy-1'-phenylethyl)-7,7-dimethyl-1H-isoindol-1-on

Guidance literature:: With hydrogen; PtO₂/C; In methanol; under 760 Torr; Ambient temperature;
DOI:10.1002/hlca.19900730816

Reference yield:

: 77704-70-2
(-)-(R)-N-<(Furan-2-yl)methyl>-N-(2-hyydroxy-1-phenylethyl)-3-methylbut-2-enamid

: 77704-41-7
(1S,5S,7R)-3-((R)-2-Hydroxy-1-phenyl-ethyl)-6,6-dimethyl-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]decan-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 50 h / Heating

2: H₂ / Pd/C

With hydrogen; palladium on activated charcoal; In toluene;
DOI:10.1246/cl.1981.29

Reference yield:

: 98-01-1
furfural

: 77704-41-7
(-)-(3aR,6S,7aS,1'R)-3a,6-Epoxyperhydro-2-(2'-hydroxy-1'-phenylethyl)-7,7-dimethyl-1H-isoindol-1-on

Guidance literature:: Multi-step reaction with 5 steps

1: 2) NaBH₄ / 1) toluene, reflux, 2) i-PrOH, r.t., 2h

2: 82 percent / pyridine / tetrahydrofuran / 3 h / 0 °C

3: 88 percent / H₂O, K₂CO₃ / methanol; CH₂Cl₂ / 2.5 h / Heating

4: 60 percent / BuMgBr / a) Et₂O, -60 deg C, 40 min, b) toluene, reflux, 20h

5: 97 percent / H₂ / PtO₂/C / methanol / 760 Torr / Ambient temperature

With pyridine; n-butyl magnesium bromide; sodium tetrahydroborate; water; hydrogen; potassium carbonate; PtO₂/C; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/hlca.19900730816