2-Phenoxyacetohydrazide

Base Information

• Chemical Name: 2-Phenoxyacetohydrazide
• CAS No.: 4664-55-5
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 2928000090
• European Community (EC) Number: 809-469-3
• NSC Number: 409846
• UNII: K4H72K4AR3
• DSSTox Substance ID: DTXSID20196893
• Nikkaji Number: J150.897K
• Wikidata: Q83069879
• Mol file: 4664-55-5.mol

Synonyms:2-Phenoxyacetohydrazide;4664-55-5;Phenoxyacetic acid hydrazide;Acetic acid, phenoxy-, hydrazide;Phenoxy-Acetic Acid Hydrazide;MFCD00297030;PC 603;NSC-409846;Maybridge4_003484;2-Phenoxyacetohydrazide #;PHENOXYACETOHYDRAZIDE;Cambridge id 5153128;Oprea1_309738;Oprea1_829554;PHENOXYACETIC HYDRAZIDE;(PHENOXYACETYL)HYDRAZINE;K4H72K4AR3;SCHEMBL1272486;XSONSBDQIFBIOY-UHFFFAOYSA-;DTXSID20196893;XSONSBDQIFBIOY-UHFFFAOYSA-N;HMS1530O08;2-Phenoxyacetohydrazide, AldrichCPR;NSC409846;STK081051;AKOS000160038;NSC 409846;SB86009;NCGC00175795-01;AS-11237;ACETIC ACID, 2-PHENOXY-, HYDRAZIDE;BB 0240526;CS-0116734;D84136;EN300-1265889;A924245;F0777-0786;F1236-0003;InChI=1/C8H10N2O2/c9-10-8(11)6-12-7-4-2-1-3-5-7/h1-5H,6,9H2,(H,10,11)

Chemical Property of 2-Phenoxyacetohydrazide

Chemical Property:

• Vapor Pressure: 2.63E-06mmHg at 25°C
• Melting Point: 112 °C
• Refractive Index: 1.553
• Boiling Point: 390.5 °C at 760 mmHg
• PKA: 12.01±0.18(Predicted)
• Flash Point: 190 °C
• PSA: 64.35000
• Density: 1.19 g/cm³
• LogP: 1.14650
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 166.074227566
• Heavy Atom Count: 12
• Complexity: 144

Purity/Quality:

97% ^*data from raw suppliers

Phenoxyacetic acid hydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OCC(=O)NN

Technology Process of 2-Phenoxyacetohydrazide

There total 12 articles about 2-Phenoxyacetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 2-phenoxyacetate (2065-23-8) → phenoxyacetyl hydrazine (4664-55-5)

Guidance literature:

With hydrazine hydrate; In methanol; for 0.0166667h; microwave irradiation;

DOI:10.1081/SCC-120027275

Reference yield: 98.0%

phenoxyacetic acid ethyl ester (2555-49-9) → phenoxyacetyl hydrazine (4664-55-5)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

DOI:10.1016/j.ejmech.2013.08.027

Reference yield: 91.0%

2-phenoxyacetic acid (122-59-8) → phenoxyacetyl hydrazine (4664-55-5)

Guidance literature:

With hydrazine hydrate; Vilsmeier reagent; triethylamine; In dichloromethane; at 20 ℃; for 7h;

DOI:10.1007/s11164-016-2738-x

upstream raw materials:

phenoxyacetic acid ethyl ester

methyl 2-phenoxyacetate

2-phenoxyacetic acid

phenol

Downstream raw materials:

5-bromo-3-phenoxy acetyl hydrazono-2-indolinone

phenoxy-acetic acid cyclohexylidenehydrazide

1-phenoxyacetyl-2-benzylidenehydrazine

phenoxy-acetic acid-(1-phenyl-ethylidenehydrazide)