diethyl difluoro{4-[3-hydroxy-2-(hydroxymethyl)propyl]phenyl}methylphosphonate

Base Information

Chemical Name:diethyl difluoro{4-[3-hydroxy-2-(hydroxymethyl)propyl]phenyl}methylphosphonate
CAS No.:213127-72-1
Molecular Formula:C₁₅H₂₃F₂O₅P
Molecular Weight:352.315
Hs Code.:

Synonyms:diethyl difluoro{4-[3-hydroxy-2-(hydroxymethyl)propyl]phenyl}methylphosphonate

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Chemical Property of diethyl difluoro{4-[3-hydroxy-2-(hydroxymethyl)propyl]phenyl}methylphosphonate

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Technology Process of diethyl difluoro{4-[3-hydroxy-2-(hydroxymethyl)propyl]phenyl}methylphosphonate

There total 5 articles about diethyl difluoro{4-[3-hydroxy-2-(hydroxymethyl)propyl]phenyl}methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 213127-68-5
dimethyl 2-{4-[(diethoxyphosphoryl)(difluoro)methyl]benzyl}malonate

: 213127-72-1
diethyl difluoro{4-[3-hydroxy-2-(hydroxymethyl)propyl]phenyl}methylphosphonate

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h;
DOI:10.1016/S0040-4020(98)00586-9

Reference yield:

: 65094-22-6
diethyl (bromodifluoromethyl)phosphonate

: 213127-72-1
diethyl difluoro{4-[3-hydroxy-2-(hydroxymethyl)propyl]phenyl}methylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / Zn; CuBr / N,N-dimethyl-acetamide / ultrasound

2: N-bromosuccinimide; AIBN / CCl₄ / 3 h / 90 °C

3: 71 percent / NaH / tetrahydrofuran / 0.5 h / 20 °C

4: 64 percent / NaBH₄ / methanol / 2 h / 20 °C

With sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; copper(I) bromide; zinc; In tetrahydrofuran; methanol; tetrachloromethane; N,N-dimethyl acetamide; 1: Substitution / 2: Bromination / 3: Substitution / 4: Reduction;
DOI:10.1016/S0040-4020(98)00586-9

Reference yield:

: 624-31-7
4-tolyl iodide

: 213127-72-1
diethyl difluoro{4-[3-hydroxy-2-(hydroxymethyl)propyl]phenyl}methylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / Zn; CuBr / N,N-dimethyl-acetamide / ultrasound

2: N-bromosuccinimide; AIBN / CCl₄ / 3 h / 90 °C

3: 71 percent / NaH / tetrahydrofuran / 0.5 h / 20 °C

4: 64 percent / NaBH₄ / methanol / 2 h / 20 °C

With sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; copper(I) bromide; zinc; In tetrahydrofuran; methanol; tetrachloromethane; N,N-dimethyl acetamide; 1: Substitution / 2: Bromination / 3: Substitution / 4: Reduction;
DOI:10.1016/S0040-4020(98)00586-9