ethyl 2-((1S,2S,5S,6S)-2-formyl-2,6-dimethyl-5-((triisopropylsilyl)oxy)cyclohexyl)acetate

Base Information

Chemical Name:ethyl 2-((1S,2S,5S,6S)-2-formyl-2,6-dimethyl-5-((triisopropylsilyl)oxy)cyclohexyl)acetate
CAS No.:1569075-93-9
Molecular Formula:C₂₂H₄₂O₄Si
Molecular Weight:398.659
Hs Code.:

Synonyms:ethyl 2-((1S,2S,5S,6S)-2-formyl-2,6-dimethyl-5-((triisopropylsilyl)oxy)cyclohexyl)acetate

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Chemical Property of ethyl 2-((1S,2S,5S,6S)-2-formyl-2,6-dimethyl-5-((triisopropylsilyl)oxy)cyclohexyl)acetate

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Technology Process of ethyl 2-((1S,2S,5S,6S)-2-formyl-2,6-dimethyl-5-((triisopropylsilyl)oxy)cyclohexyl)acetate

There total 3 articles about ethyl 2-((1S,2S,5S,6S)-2-formyl-2,6-dimethyl-5-((triisopropylsilyl)oxy)cyclohexyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1569075-92-8
ethyl 2-((1S,2S,5S,6S)-2-((benzylthio)carbonyl)-2,6-dimethyl-5-((triisopropylsilyl)oxy)cyclohexyl)acetate

: 1569075-93-9
ethyl 2-((1S,2S,5S,6S)-2-formyl-2,6-dimethyl-5-((triisopropylsilyl)oxy)cyclohexyl)acetate

Guidance literature:: With triethylsilane; palladium diacetate; In acetone; at 20 ℃; for 0.0833333h; Inert atmosphere;
DOI:10.1016/j.tetlet.2014.01.071

Reference yield:

: 1549824-53-4
(1S,2S,3S,4S)-phenyl-2-(2-ethoxy-2-oxoethyl)-1,3-dimethyl-4-(triisopropylsilyloxy)cyclohexanecarboxylate

: 1569075-93-9
ethyl 2-((1S,2S,5S,6S)-2-formyl-2,6-dimethyl-5-((triisopropylsilyl)oxy)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C / Inert atmosphere

2: triethylsilane; palladium diacetate / acetone / 0.08 h / 20 °C / Inert atmosphere

With triethylsilane; palladium diacetate; potassium carbonate; In N,N-dimethyl-formamide; acetone; 2: |Fukuyama Reduction;
DOI:10.1016/j.tetlet.2014.01.071

Reference yield:

: C₂₈H₄₄O₅Si

: 1569075-93-9
ethyl 2-((1S,2S,5S,6S)-2-formyl-2,6-dimethyl-5-((triisopropylsilyl)oxy)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: L-Selectride / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / -78 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C / Inert atmosphere

3: triethylsilane; palladium diacetate / acetone / 0.08 h / 20 °C / Inert atmosphere

With triethylsilane; palladium diacetate; L-Selectride; potassium carbonate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; acetone; 1: |Michael Addition / 3: |Fukuyama Reduction;
DOI:10.1016/j.tetlet.2014.01.071