Technology Process of 2-{(1S,2R,5S,6S)-2-[(E)-6-iodo-3,3-dimethoxyhepta-1,6-dien-1-yl]-2,6-dimethyl-5-triisopropylsilyloxycyclohexyl}acetaldehyde
There total 8 articles about 2-{(1S,2R,5S,6S)-2-[(E)-6-iodo-3,3-dimethoxyhepta-1,6-dien-1-yl]-2,6-dimethyl-5-triisopropylsilyloxycyclohexyl}acetaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine; Dess-Martin periodane;
In
dichloromethane;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
DOI:10.1016/j.tetlet.2014.01.071
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere
1.2: 3 h / 110 °C / Inert atmosphere
2.1: toluene-4-sulfonic acid; triethylamine / methanol / 0.17 h / 80 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / hexane; dichloromethane / 2 h / Inert atmosphere; Cooling
4.1: Dess-Martin periodane; pyridine / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
With
pyridine; sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine;
In
1,4-dioxane; methanol; hexane; dichloromethane;
1.1: |Horner-Wadsworth-Emmons Olefination / 1.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.tetlet.2014.01.071
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: L-Selectride / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / -78 °C / Inert atmosphere
2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C / Inert atmosphere
3.1: triethylsilane; palladium diacetate / acetone / 0.08 h / 20 °C / Inert atmosphere
4.1: sodium hydride / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere
4.2: 3 h / 110 °C / Inert atmosphere
5.1: toluene-4-sulfonic acid; triethylamine / methanol / 0.17 h / 80 °C / Inert atmosphere
6.1: diisobutylaluminium hydride / hexane; dichloromethane / 2 h / Inert atmosphere; Cooling
7.1: Dess-Martin periodane; pyridine / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
With
pyridine; triethylsilane; palladium diacetate; L-Selectride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; N,N-dimethyl-formamide; acetone;
1.1: |Michael Addition / 3.1: |Fukuyama Reduction / 4.1: |Horner-Wadsworth-Emmons Olefination / 4.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.tetlet.2014.01.071
