1,1-Dimethyl-4-oxopiperidin-1-ium iodide

Base Information

• Chemical Name: 1,1-Dimethyl-4-oxopiperidin-1-ium iodide
• CAS No.: 26822-37-7
• Molecular Formula: C7H14 N O . I
• Molecular Weight: 255.099
• Hs Code.: 2933399090
• NSC Number: 149999
• DSSTox Substance ID: DTXSID50456992
• Mol file: 26822-37-7.mol

Synonyms:26822-37-7;1,1-dimethyl-4-oxopiperidin-1-ium iodide;1,1,-DIMETHYL-4-OXOPIPERIDINIUM IODIDE;PIPERIDINIUM,1,1-DIMETHYL-4-OXO-,IODIDE;1,1-dimethylpiperidin-1-ium-4-one;iodide;1,1-Dimethyl-4-oxo-1-piperidinium iodide;1,1-Dimethylpiperidin-1-ium-4-one iodide;MFCD00466081;1,1-dimethyl-4-oxopiperidinium iodide;1,1-DIMETHYL-4-OXO-PIPERIDINIUM IODIDE;Piperidinium, 1,1-dimethyl-4-oxo-, iodide;C7H14INO;SCHEMBL4041064;N-Methyl-4-piperidone methodide;DTXSID50456992;LMQPCACOOKKMHW-UHFFFAOYSA-M;BBA82237;NSC149999;AKOS022173406;NSC 149999;NSC-149999;1,1-dimethyl-4 -oxopiperidinium iodide;Piperidinium,1-dimethyl-4-oxo-, iodide;AS-44480;AM20090330;CS-0309093;FT-0722715;EN300-156694

Chemical Property of 1,1-Dimethyl-4-oxopiperidin-1-ium iodide

Chemical Property:

• Melting Point: 174-179 °C (decomp)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 17.07000
• Density: g/cm³
• LogP: -2.61150
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 255.01201
• Heavy Atom Count: 10
• Complexity: 117

Purity/Quality:

99% ^*data from raw suppliers

1,1-Dimethyl-4-oxopiperidin-1-iumiodide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[N+]1(CCC(=O)CC1)C.[I-]

Technology Process of 1,1-Dimethyl-4-oxopiperidin-1-ium iodide

There total 8 articles about 1,1-Dimethyl-4-oxopiperidin-1-ium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-Methyl-4-piperidone (1445-73-4) + methyl iodide (74-88-4) → N,N-dimethyl-4-oxopiperidinium iodide (26822-37-7)

Guidance literature:

In acetone;

DOI:10.1021/jo061618f

Reference yield:

1-Methyl-4-piperidone (1445-73-4) + di-isopropyl ether (108-20-3) + methyl iodide (74-88-4) → N,N-dimethyl-4-oxopiperidinium iodide (26822-37-7)

Guidance literature:

In dichloromethane;

Reference yield:

1-Methyl-4-piperidone (1445-73-4) + methyl iodide (74-88-4) → N,N-dimethyl-4-oxopiperidinium iodide (26822-37-7) + 4,4-Dihydroxy-1,1-dimethylpiperidinium-iodid (26822-30-0)

Guidance literature:

In acetone; at 25 - 30 ℃; for 2h; Title compound not separated from byproducts;

DOI:10.1021/jo048047g

upstream raw materials:

1-Methyl-4-piperidone

methyl iodide

di-isopropyl ether

ethyl 1-methyl-4-oxo-piperidin-3-carboxylate

Downstream raw materials:

1-α-phenylethyl-4-piperidone

1-tert-butyl-piperidin-4-one

8-isopropyl-3-methyl-2-oxo-N-[4-(trifluoromethyl)benzyl]-1-oxa-8-azaspiro[4.5]dec-3-ene-4-carboxamide

8-isopropyl-3-methyl-2-oxo-1-oxa-8-aza-spiro[4.5]dec-3-ene-4-carboxylic acid 2-tert-butoxy-5-trifluoromethyl-benzylamide

Refernces

• 1、 -. "TRICYCLIC DEGRADERS OF IKAROS AND AIOLOS". Page/Page column 558. . Retrieved 2020/10/21.
• 2、 Thavornpradit, Sopida,Usama, Syed Muhammad,Lin, Chen-Ming,Burgess, Kevin. "Protein labelling and albumin binding characteristics of the near-IR Cy7 fluorophore, QuatCy". supporting information. p. 7150 - 7154. Retrieved 2019/08/07.