7-(8-oxabicyclo[3.2.1]octan-3-yloxy)-N-(4-(3-chloro-4-fluorophenyl))quinazolin-4,6-diamine

Base Information

Chemical Name:7-(8-oxabicyclo[3.2.1]octan-3-yloxy)-N-(4-(3-chloro-4-fluorophenyl))quinazolin-4,6-diamine
CAS No.:1363359-56-1
Molecular Formula:C₂₁H₂₀ClFN₄O₂
Molecular Weight:414.867
Hs Code.:

Synonyms:7-(8-oxabicyclo[3.2.1]octan-3-yloxy)-N-(4-(3-chloro-4-fluorophenyl))quinazolin-4,6-diamine

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Chemical Property of 7-(8-oxabicyclo[3.2.1]octan-3-yloxy)-N-(4-(3-chloro-4-fluorophenyl))quinazolin-4,6-diamine

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Technology Process of 7-(8-oxabicyclo[3.2.1]octan-3-yloxy)-N-(4-(3-chloro-4-fluorophenyl))quinazolin-4,6-diamine

There total 6 articles about 7-(8-oxabicyclo[3.2.1]octan-3-yloxy)-N-(4-(3-chloro-4-fluorophenyl))quinazolin-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1363359-55-0
7-(8-oxabicyclo[3.2.1]octan-3-yloxy)-N-(4-(3-chloro-4-fluorophenyl))-6-nitroquinazolin-4-amine

: 1363359-56-1
7-(8-oxabicyclo[3.2.1]octan-3-yloxy)-N-(4-(3-chloro-4-fluorophenyl))quinazolin-4,6-diamine

Guidance literature:: With iron; acetic acid; In ethanol;

Reference yield:

: 162012-69-3
7-fluoro-6-nitro-3H-quinazolin-4-one

: 1363359-56-1
7-(8-oxabicyclo[3.2.1]octan-3-yloxy)-N-(4-(3-chloro-4-fluorophenyl))quinazolin-4,6-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride

2.1: isopropyl alcohol

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

3.2: 20 °C

4.1: acetic acid; iron / ethanol

With thionyl chloride; iron; sodium hydride; acetic acid; In ethanol; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

Reference yield:

: 16499-57-3
7-fluoro-3H-quinazolin-4-one

: 1363359-56-1
7-(8-oxabicyclo[3.2.1]octan-3-yloxy)-N-(4-(3-chloro-4-fluorophenyl))quinazolin-4,6-diamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitric acid; sulfuric acid

2.1: thionyl chloride

3.1: isopropyl alcohol

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

4.2: 20 °C

5.1: acetic acid; iron / ethanol

With thionyl chloride; sulfuric acid; nitric acid; iron; sodium hydride; acetic acid; In ethanol; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;