N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

Base Information Edit

Chemical Name:N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
CAS No.:162012-67-1
Molecular Formula:C14H7ClF4N4O2
Molecular Weight:336.685
Hs Code.:2933990090
European Community (EC) Number:808-276-1
DSSTox Substance ID:DTXSID60442902
Wikidata:Q72451198
Mol file:162012-67-1.mol

Synonyms:162012-67-1;N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine;4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquninazoline;4-QUINAZOLINAMINE, N-(3-CHLORO-4-FLUOROPHENYL)-7-FLUORO-6-NITRO-;MFCD09998825;N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine;4-[(3-chloro-4-fluorophenyl)amino]-7-fluoro-6-nitroquinazoline;(3-Chloro-4-fluoro-phenyl)-(7-fluoro-6-nitro-quinazolin-4-yl)-amine;C14H7ClF2N4O2;SCHEMBL25241;AMY6970;DTXSID60442902;BCP08568;CS-M0991;N-(3-chloro-4-fluoro-phenyl)-7-fluoro-6-nitro-quinazolin-4-amine;AKOS015917847;AKOS034830279;PB34506;AC-27054;AS-11445;SY028080;A3594;C3276;FT-0687659;A810325;4-(3-chloro-4-fluorophenyl)amino-6-nitro-7-fluoroquinazoline;6-nitro-4-(3-chloro-4-fluorophenylamino)-7-fluoro-quinazoline;4-[(3-chloro-4-fluoro-phenyl)amino]-7-fluoro-6-nitro-quinazoline;4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-fluoro-quinazoline;4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-fluoroquinazoline;N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazoline-4-amine;(3-Chloro-4-fluoro-phenyl)-(7-fluoro-6-nitro-quinazoline-4-yl)-amine;(3-CHLORO-4-FLUOROPHENYL)(7-FLUORO-6-NITROQUINAZOLIN-4-YL)AMINE;4-(3-CHLORO-4-FLUORO-PHENYLAMINO)-7-FLUORO-6-NITROQUNINAZOLINE

Suppliers and Price of N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquinazoline
100mg
$ 95.00

TRC
4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquinazoline
10g
$ 970.00

TCI Chemical
N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine
25G
$ 436.00

TCI Chemical
N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine
5G
$ 146.00

SynQuest Laboratories
N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine 97%
25 g
$ 180.00

SynQuest Laboratories
N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine 97%
5 g
$ 50.00

SynQuest Laboratories
N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine 97%
1 g
$ 35.00

Matrix Scientific
N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine 95+%
1g
$ 1428.00

Matrix Scientific
N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine 95+%
250mg
$ 643.00

Crysdot
N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine 98%
25g
$ 81.00

Total 163 raw suppliers

Chemical Property of N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine Edit

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:242-244℃
Refractive Index:1.707
Boiling Point:488.589 °C at 760 mmHg
PKA:5.07±0.70(Predicted)
Flash Point:249.29 °C
PSA：83.63000
Density:1.617 g/cm³
LogP:4.80940
Storage Temp.:2-8°C(protect from light)
Solubility.:DMSO (Slightly), Methanol (Slightly, Sonicated)
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:336.0225595
Heavy Atom Count:23
Complexity:442

Purity/Quality:

99% ^*data from raw suppliers

4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquinazoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1NC2=NC=NC3=CC(=C(C=C32)[N+](=O)[O-])F)Cl)F
Uses 4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquninazoline is an intermediate in the synthesis of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

Technology Process of N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

There total 18 articles about N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 367-21-5
3-chloro-4-fluorophenylamine

: 162012-70-6
4-chloro-7-fluoro-6-nitroquinazoline

: 162012-67-1
N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

Guidance literature:: In isopropyl alcohol; for 4h; Product distribution / selectivity; Reflux;

Reference yield: 96.0%

: 2-bromo-N-(3-chloro-4-fluorophenyl)-4-fluoro-5-nitrobenzene-carboxamidine

: 77287-34-4,77287-35-5,60100-09-6
formamide

: 162012-67-1
N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

Guidance literature:: With copper(l) iodide; potassium carbonate; 4-hydroxyproline; In N,N-dimethyl-formamide; at 80 ℃; for 0.166667h; Reagent/catalyst; Temperature; Time; Microwave irradiation;