1-<3-O-(methylsulfonyl)-5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil

Base Information

• Chemical Name: 1-<3-O-(methylsulfonyl)-5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil
• CAS No.: 124424-33-5
• Molecular Formula: C₃₀H₂₉FN₂O₈S
• Molecular Weight: 596.633
• Mol file: 124424-33-5.mol

Synonyms:1-<3-O-(methylsulfonyl)-5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil

Chemical Property of 1-<3-O-(methylsulfonyl)-5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<3-O-(methylsulfonyl)-5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil

There total 4 articles about 1-<3-O-(methylsulfonyl)-5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-<5-O-(momomethoxytrityl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>uracil (124424-27-7) + methanesulfonyl chloride (124-63-0) → 1-<3-O-(methylsulfonyl)-5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil (124424-33-5)

Guidance literature:

With pyridine; at 0 ℃; for 16h;

DOI:10.1021/jm00170a017

Reference yield:

fialuridine (69123-98-4) → 1-<3-O-(methylsulfonyl)-5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil (124424-33-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 90.3 percent / H₂, Et₃N / 10percent Pd/C / methanol; H₂O / 18 h / 2068.6 Torr

2: 89.3 percent / pyridine / 18 h / Ambient temperature

3: 100 percent / pyridine / 16 h / 0 °C

With pyridine; hydrogen; triethylamine; palladium on activated charcoal; In methanol; water;

DOI:10.1021/jm00170a017

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → 1-<3-O-(methylsulfonyl)-5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil (124424-33-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 89.3 percent / pyridine / 18 h / Ambient temperature

2: 100 percent / pyridine / 16 h / 0 °C

With pyridine;

DOI:10.1021/jm00170a017

upstream raw materials:

1-<5-O-(momomethoxytrityl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>uracil

methanesulfonyl chloride

mono-4-methoxytrityl chloride

1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)uracil

Downstream raw materials:

O-2,3'-anhydro-1-<5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-lyxofuranosyl>uracil

1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl>cytosine

1-<5-O-(momomethoxytrityl)-2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl>uracil

1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl>cytosine