(S)-3-[(S)-3-(1-Benzyl-1H-imidazol-4-yl)-butyryl]-4-phenyl-oxazolidin-2-one

Base Information

Chemical Name:(S)-3-[(S)-3-(1-Benzyl-1H-imidazol-4-yl)-butyryl]-4-phenyl-oxazolidin-2-one
CAS No.:409102-38-1
Molecular Formula:C₂₃H₂₃N₃O₃
Molecular Weight:389.454
Hs Code.:

Synonyms:(S)-3-[(S)-3-(1-Benzyl-1H-imidazol-4-yl)-butyryl]-4-phenyl-oxazolidin-2-one

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Chemical Property of (S)-3-[(S)-3-(1-Benzyl-1H-imidazol-4-yl)-butyryl]-4-phenyl-oxazolidin-2-one

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Technology Process of (S)-3-[(S)-3-(1-Benzyl-1H-imidazol-4-yl)-butyryl]-4-phenyl-oxazolidin-2-one

There total 1 articles about (S)-3-[(S)-3-(1-Benzyl-1H-imidazol-4-yl)-butyryl]-4-phenyl-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 75-16-1
methylmagnesium bromide

: (S)-3-[(E)-3-(1-Benzyl-1H-imidazol-4-yl)-acryloyl]-4-phenyl-oxazolidin-2-one

: 409102-38-1
(S)-3-[(S)-3-(1-Benzyl-1H-imidazol-4-yl)-butyryl]-4-phenyl-oxazolidin-2-one

: (S)-3-[(R)-3-(1-Benzyl-1H-imidazol-4-yl)-butyryl]-4-phenyl-oxazolidin-2-one

Guidance literature:: With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at -40 ℃; for 12h;
DOI:10.1021/ja0177814

Reference yield: 72.0%

: 409102-38-1
(S)-3-[(S)-3-(1-Benzyl-1H-imidazol-4-yl)-butyryl]-4-phenyl-oxazolidin-2-one

: 409102-40-5
(S)-3-[(2S,3S)-2-Azido-3-(1-benzyl-1H-imidazol-4-yl)-butyryl]-4-phenyl-oxazolidin-2-one

Guidance literature:: (S)-3-[(S)-3-(1-Benzyl-1H-imidazol-4-yl)-butyryl]-4-phenyl-oxazolidin-2-one; With potassium hexamethylsilazane; In tetrahydrofuran; at -50 ℃;

With 2,4,6-Triisopropylbenzenesulfonyl azide; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/j.tet.2006.01.104

Reference yield:

: 409102-38-1
(S)-3-[(S)-3-(1-Benzyl-1H-imidazol-4-yl)-butyryl]-4-phenyl-oxazolidin-2-one

: (2S,3S)-2-Amino-3-(1-benzyl-1H-imidazol-4-yl)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: KHMDS / tetrahydrofuran / -50 °C

1.2: 72 percent / trisyl azide / tetrahydrofuran / -78 °C

2.1: 75 percent / NaOMe / CH₂Cl₂ / -10 °C

3.1: H₂; acetic acid / Pd/C / methanol

With hydrogen; sodium methylate; potassium hexamethylsilazane; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tet.2006.01.104