4-[2,2-dimethyl-4,6-dioxo-5-(3-tritylsulfanylpropyl)[1,3]dioxan-5-ylmethyl]benzoic acid methyl ester

Base Information

Chemical Name:4-[2,2-dimethyl-4,6-dioxo-5-(3-tritylsulfanylpropyl)[1,3]dioxan-5-ylmethyl]benzoic acid methyl ester
CAS No.:891200-58-1
Molecular Formula:C₃₇H₃₆O₆S
Molecular Weight:608.755
Hs Code.:

Synonyms:4-[2,2-dimethyl-4,6-dioxo-5-(3-tritylsulfanylpropyl)[1,3]dioxan-5-ylmethyl]benzoic acid methyl ester

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Chemical Property of 4-[2,2-dimethyl-4,6-dioxo-5-(3-tritylsulfanylpropyl)[1,3]dioxan-5-ylmethyl]benzoic acid methyl ester

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Technology Process of 4-[2,2-dimethyl-4,6-dioxo-5-(3-tritylsulfanylpropyl)[1,3]dioxan-5-ylmethyl]benzoic acid methyl ester

There total 1 articles about 4-[2,2-dimethyl-4,6-dioxo-5-(3-tritylsulfanylpropyl)[1,3]dioxan-5-ylmethyl]benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 254737-40-1
2,2-dimethyl-5-[3-[(triphenylmethyl)thio]propyl]-[1,3]dioxane-4,6-dione

: 891200-58-1
4-[2,2-dimethyl-4,6-dioxo-5-(3-tritylsulfanylpropyl)[1,3]dioxan-5-ylmethyl]benzoic acid methyl ester

Guidance literature:: 2,2-dimethyl-5-[3-[(triphenylmethyl)thio]propyl]-[1,3]dioxane-4,6-dione; With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In acetonitrile; at 75 ℃; for 0.333333h;

Methyl 4-(bromomethyl)benzoate; In acetonitrile; at 75 ℃; for 5h;
DOI:10.1021/jm051019l

Reference yield:

: 891200-58-1
4-[2,2-dimethyl-4,6-dioxo-5-(3-tritylsulfanylpropyl)[1,3]dioxan-5-ylmethyl]benzoic acid methyl ester

: 891200-66-1
2-(4-carboxy-benzyl)-2-(3-tritylsulfanyl-propyl)-malonic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 100 ℃; for 3h;
DOI:10.1021/jm051019l

Reference yield:

: 891200-58-1
4-[2,2-dimethyl-4,6-dioxo-5-(3-tritylsulfanylpropyl)[1,3]dioxan-5-ylmethyl]benzoic acid methyl ester

: 4-carboxy-alpha-(3-mercaptopropyl)-benzenepropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaOH / dioxane / 3 h / 100 °C

2: dimethylsulfoxide / 3 h / 130 °C

3: 90 percent / trifluoroacetic acid; triisopropylsilane / CH₂Cl₂ / 0.5 h / 20 °C

With sodium hydroxide; chlorotriisopropylsilane; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm051019l