2'-methoxyphenyl (4S,5R)-4-(4-methoxyphenyl)-2-oxo-oxazolidin-5-carboxylate

Base Information

Chemical Name:2'-methoxyphenyl (4S,5R)-4-(4-methoxyphenyl)-2-oxo-oxazolidin-5-carboxylate
CAS No.:743430-72-0
Molecular Formula:C₁₈H₁₇NO₆
Molecular Weight:343.336
Hs Code.:

Synonyms:2'-methoxyphenyl (4S,5R)-4-(4-methoxyphenyl)-2-oxo-oxazolidin-5-carboxylate

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Chemical Property of 2'-methoxyphenyl (4S,5R)-4-(4-methoxyphenyl)-2-oxo-oxazolidin-5-carboxylate

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Technology Process of 2'-methoxyphenyl (4S,5R)-4-(4-methoxyphenyl)-2-oxo-oxazolidin-5-carboxylate

There total 3 articles about 2'-methoxyphenyl (4S,5R)-4-(4-methoxyphenyl)-2-oxo-oxazolidin-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 743430-71-9
(4S,5R)-5-(o-anisoyl)-4-(4-methoxyphenyl)-2-oxazolidinone

: 743430-72-0
2'-methoxyphenyl (4S,5R)-4-(4-methoxyphenyl)-2-oxo-oxazolidin-5-carboxylate

Guidance literature:: With sodium dihydrogenphosphate; 3-chloro-benzenecarboperoxoic acid; In 1,2-dichloro-ethane; at 60 ℃; for 3h;
DOI:10.1021/ja0482435

Reference yield:

: 743430-44-6
tert-butyl 4-methoxybenzylidenecarbamate

: 743430-72-0
2'-methoxyphenyl (4S,5R)-4-(4-methoxyphenyl)-2-oxo-oxazolidin-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-bis[(S,S)-BINOL-3-yl]dimethyl ether; Et₂Zn; molecular sieves 3 Angstroem / diethyl ether; hexane; tetrahydrofuran / 25 h / -40 °C

2.1: TFA; anisole / 0.08 h / 20 °C

2.2: 92 percent / pyridine / CH₂Cl₂ / 0.5 h / -78 °C

3.1: 63 percent / m-CPBA; NaH₂PO₄ / 1,2-dichloro-ethane / 3 h / 60 °C

With sodium dihydrogenphosphate; 1,1'-bis[(S,S)-BINOL-3-yl]dimethyl ether; 3 A molecular sieve; diethylzinc; methoxybenzene; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; hexane; 1,2-dichloro-ethane; 3.1: Baeyer-Villiger oxidation;
DOI:10.1021/ja0482435

Reference yield:

: 743430-56-0
(2R,3S)-2-hydroxy-1-(2-methoxyphenyl)-3-(4-methoxyphenyl)-3-(N-tert-butoxycarbonylamino)-1-propanone

: 743430-72-0
2'-methoxyphenyl (4S,5R)-4-(4-methoxyphenyl)-2-oxo-oxazolidin-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: TFA; anisole / 0.08 h / 20 °C

1.2: 92 percent / pyridine / CH₂Cl₂ / 0.5 h / -78 °C

2.1: 63 percent / m-CPBA; NaH₂PO₄ / 1,2-dichloro-ethane / 3 h / 60 °C

With sodium dihydrogenphosphate; methoxybenzene; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In 1,2-dichloro-ethane; 2.1: Baeyer-Villiger oxidation;
DOI:10.1021/ja0482435