(4S,5R)-5-(hydroxymethyl)-4-(4-methoxyphenyl)-1,3-oxazolidin-2-one

Base Information

• Chemical Name: (4S,5R)-5-(hydroxymethyl)-4-(4-methoxyphenyl)-1,3-oxazolidin-2-one
• CAS No.: 237736-11-7
• Molecular Formula: C11H13NO4
• Molecular Weight: 223.229
• DSSTox Substance ID: DTXSID00473553
• Nikkaji Number: J1.106.370E
• Wikidata: Q82303033
• Mol file: 237736-11-7.mol

Synonyms:237736-11-7;CTK0J5439;DTXSID00473553

Chemical Property of (4S,5R)-5-(hydroxymethyl)-4-(4-methoxyphenyl)-1,3-oxazolidin-2-one

Chemical Property:

• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 223.08445790
• Heavy Atom Count: 16
• Complexity: 250

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2C(OC(=O)N2)CO
• Isomeric SMILES: COC1=CC=C(C=C1)[C@H]2[C@@H](OC(=O)N2)CO

Technology Process of (4S,5R)-5-(hydroxymethyl)-4-(4-methoxyphenyl)-1,3-oxazolidin-2-one

There total 79 articles about (4S,5R)-5-(hydroxymethyl)-4-(4-methoxyphenyl)-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(4S,5R)-5-Benzyloxymethyl-4-(4-methoxy-phenyl)-oxazolidin-2-one → (-)-(4S,5R)-5-hydroxymethyl-4-(4-methoxyphenyl)-1,3-oxazolidin-2-one (237736-11-7,220736-25-4,259794-13-3)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; at 23 ℃; for 24h; under 760 Torr;

DOI:10.1016/S0960-894X(03)00131-8

Reference yield: 99.0%

(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-phenyl)-oxazolidin-2-one (237736-20-8) → (-)-(4S,5R)-5-hydroxymethyl-4-(4-methoxyphenyl)-1,3-oxazolidin-2-one (237736-11-7,220736-25-4,259794-13-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/S0040-4039(99)00712-1

Reference yield: 99.0%

[(4S,5R)-4-(4-methoxyphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl (1S,4R)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carboxylate (701975-99-7) → (-)-(4S,5R)-5-hydroxymethyl-4-(4-methoxyphenyl)-1,3-oxazolidin-2-one (237736-11-7,220736-25-4,259794-13-3)

Guidance literature:

With potassium hydroxide; In methanol; at 20 ℃; for 0.5h;

DOI:10.1016/j.tet.2004.02.048

upstream raw materials:

(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(4-methoxy-phenyl)-oxazolidin-2-one

(4S,5R)-4-(4-Methoxy-phenyl)-2-oxo-oxazolidine-5-carboxylic acid ethyl ester

vinyl acetate

trans-5-(hydroxymethyl)-4-(4-methoxyphenyl)-1,3-oxazolidin-2-one