4-bis(2-hydroxyethyl)amino-L-phenylalanine

Base Information

• Chemical Name: 4-bis(2-hydroxyethyl)amino-L-phenylalanine
• CAS No.: 72143-20-5
• Molecular Formula: C₁₃H₂₀N₂O₄
• Molecular Weight: 268.313
• Mol file: 72143-20-5.mol

Synonyms:Alanine,3-[p-[bis(2-hydroxyethyl)amino]phenyl]- (6CI)

Chemical Property of 4-bis(2-hydroxyethyl)amino-L-phenylalanine

Chemical Property:

• Vapor Pressure: 1.27E-11mmHg at 25°C
• Boiling Point: 519.6°C at 760 mmHg
• PKA: 2.12±0.10(Predicted)
• Flash Point: 268°C
• PSA: 107.02000
• Density: 1.318g/cm³
• LogP: 0.13230
• Storage Temp.: -20°C Freezer
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

> 95% ^*data from raw suppliers

DihydroxyMelphatalan ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dihydroxy Melphatalan is an analogue of Melphalan (M216900), an antineoplastic.

Technology Process of 4-bis(2-hydroxyethyl)amino-L-phenylalanine

There total 3 articles about 4-bis(2-hydroxyethyl)amino-L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.5%

melphalan hydrochloride (3223-07-2,4213-32-5) → C13H20N2O4 (72143-20-5) + monohydroxymelphalan (61733-01-5)

Guidance literature:

With water; at 37 ℃; for 2h;

DOI:10.1021/bc900453f

Reference yield:

L-PAM (148-82-3,8057-25-8) → C13H20N2O4 (72143-20-5) + C26H37ClN4O6 + C26H37ClN4O6 + C26H36Cl2N4O5 + C26H36Cl2N4O5 + C26H36Cl2N4O5 + C26H36Cl2N4O5 + C26H36Cl2N4O5 + C26H35Cl3N4O4 + C26H35Cl3N4O4 + C26H38N4O7 + C26H38N4O7 + C26H38N4O7 + C26H37ClN4O6 + C26H37ClN4O6 + C26H37ClN4O6 + monohydroxymelphalan (61733-01-5)

Guidance literature:

With water; at 37 ℃; for 3h;

DOI:10.1002/rcm.6515

Reference yield:

L-PAM (148-82-3,8057-25-8) → C13H20N2O4 (72143-20-5)

Guidance literature:

With water;

DOI:10.1021/acs.molpharmaceut.6b00130

upstream raw materials:

melphalan hydrochloride

L-PAM

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