Melphalan hydrochloride

Base Information Edit

Chemical Name:Melphalan hydrochloride
CAS No.:3223-07-2
Molecular Formula:C₁₃H₁₈Cl₂N₂O₂*ClH
Molecular Weight:341.665
Hs Code.:2922499990
European Community (EC) Number:643-091-8
NSC Number:8806
UNII:1VXP4V453T
DSSTox Substance ID:DTXSID60872785
Wikidata:Q27252967
NCI Thesaurus Code:C48002
RXCUI:235857
ChEMBL ID:CHEMBL1200863
Mol file:3223-07-2.mol

Synonyms:Melphalan hydrochloride;3223-07-2;Melphalan HCl;Alkeran hydrochloride;CB 3025 hydrochloride;Phenylalanine mustard hydrochloride;L-Sarcolysine hydrochloride;Sarcolysin hydrochloride, l-;ALANINE, 3-(p-(BIS(2-CHLOROETHYL)AMINO)PHENYL)-, MONOHYDROCHLORIDE, L-;1VXP4V453T;CB-3025 HYDROCHLORIDE;L-Phenylalanine mustard hydrochloride;(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid;hydrochloride;Melfalan hydrochloride;4-Bis(2-chlorethyl)-amino-L-phenylalanine hydrochloride;L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-, monohydrochloride;(S)-2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanoic acid hydrochloride;NSC8806;NSC 8806;Alanine nitrogen mustard hydrochloride;AI3-26377;WLN: QVYZ1R DN2G2G &GH;Evomela (TN);L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine monohydrochloride;L-Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, hydrochloride;Alkeran (GlaxoSmith);UNII-1VXP4V453T;SCHEMBL41335;CHEMBL1200863;DTXSID60872785;L-Phenylalanine, monohydrochloride;OUUYBRCCFUEMLH-YDALLXLXSA-N;AKOS025401785;MELPHALAN HYDROCHLORIDE [VANDF];MELPHALAN HYDROCHLORIDE [USP-RS];MELPHALAN HYDROCHLORIDE [WHO-DD];AC-25549;MELPHALAN HYDROCHLORIDE [ORANGE BOOK];D08173;Q27252967;4-[bis(2-chloroethyl)-amino]-phenylalanine hydrochloride;4-[Bis(2-chloroethyl)-amino]-L-phenylalanine hydrochloride;L-PHENYLALANINE, 4-(BIS(2-CHLOROETHYL)AMINO)-, HYDROCHLORIDE (1:1);4-[bis(2-Chloroethyl)amino]-L-phenylalanine Hydrochloride (1:1);Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-, monohydrochloride, L- (8CI);L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, monohydrochloride (9CI);4-Bis(2-chloroethyl)amino-L-phenylalanine hydrochloride

Suppliers and Price of Melphalan hydrochloride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
MelphalanHydrochloride
100mg
$ 105.00

Biosynth Carbosynth
Melphalan hydrochloride
250 mg
$ 125.00

American Custom Chemicals Corporation
MELPHALAN HYDROCHLORIDE 95.00%
5MG
$ 502.94

AK Scientific
Melphalanhydrochloride
1g
$ 522.00

AK Scientific
Melphalanhydrochloride
50mg
$ 104.00

Total 38 raw suppliers

Chemical Property of Melphalan hydrochloride Edit

Chemical Property:

Vapor Pressure:9.33E-10mmHg at 25°C
Melting Point:175-178 °C
Boiling Point:473.1°Cat760mmHg
Flash Point:239.9°C
PSA：66.56000
Density:g/cm³
LogP:3.42730
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:340.051211
Heavy Atom Count:20
Complexity:265

Purity/Quality:

99.9% ^*data from raw suppliers

MelphalanHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCCl.Cl
Isomeric SMILES:C1=CC(=CC=C1C[C@@H](C(=O)O)N)N(CCCl)CCCl.Cl
Recent ClinicalTrials:High Dose Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil in Preventing Graft Versus Host Disease in Patients With Hematological Malignancies Undergoing Myeloablative or Reduced Intensity Donor Stem Cell Transplant
Recent EU Clinical Trials:Phase 1b/2 Study Combining Hepatic Percutaneous Perfusion with Ipilimumab plus Nivolumab in advanced Uveal Melanoma (CHOPIN)
Uses Melphalan Hydrochloride is used in combined intravitreal chemotherapy with topotecan hydrochloride for viable vitreous seeding from retinoblastoma. Also, it is an anti-cancer chemotherapy drug.

Technology Process of Melphalan hydrochloride

There total 13 articles about Melphalan hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 792864-20-1,93942-39-3
N-phthalimido-4-(bis-2-chloroethyl)amino-L-phenylalanine ethyl ester

: 3223-07-2,4213-32-5
melphalan hydrochloride

Guidance literature:: N-phthalimido-4-(bis-2-chloroethyl)amino-L-phenylalanine ethyl ester; With hydrogenchloride; In water; for 24h; Reflux;

With hydrogenchloride; ammonia; at 0 ℃; pH=8-8.4;