{3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid

Base Information

Chemical Name:{3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid
CAS No.:138129-13-2
Molecular Formula:C₁₉H₁₃ClN₄O₃S
Molecular Weight:412.856
Hs Code.:

Synonyms:{3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid

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Chemical Property of {3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid

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Technology Process of {3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid

There total 6 articles about {3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 138129-06-3
{3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid 4-methoxy-benzyl ester

: 138129-13-2
{3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid

Guidance literature:: With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 0.5h;
DOI:10.1021/jm00081a006

Reference yield:

: 138128-77-5
5-(hydroxymethyl)-3-(2-chlorophenyl)-1,2,4-thiadiazole

: 138129-13-2
{3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / pyridine, methanesulfonyl chloride / CH₂Cl₂ / Ambient temperature

2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 30 min

3: boron tribromide / CH₂Cl₂ / 0.5 h / -78 - 20 °C

With pyridine; boron tribromide; sodium hydride; methanesulfonyl chloride; In dichloromethane;
DOI:10.1021/jm00081a006

Reference yield:

: 138128-79-7
5-(chloromethyl)-3-(2-chlorophenyl)-1,2,4-thiadiazole

: 138129-13-2
{3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 30 min

2: boron tribromide / CH₂Cl₂ / 0.5 h / -78 - 20 °C

With boron tribromide; sodium hydride; In dichloromethane;
DOI:10.1021/jm00081a006