{3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid 4-methoxy-benzyl ester

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Chemical Name:{3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid 4-methoxy-benzyl ester
CAS No.:138129-06-3
Molecular Formula:C₂₇H₂₁ClN₄O₄S
Molecular Weight:533.007
Hs Code.:

Synonyms:{3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid 4-methoxy-benzyl ester

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Chemical Property of {3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid 4-methoxy-benzyl ester

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Technology Process of {3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid 4-methoxy-benzyl ester

There total 5 articles about {3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid 4-methoxy-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 138128-77-5
5-(hydroxymethyl)-3-(2-chlorophenyl)-1,2,4-thiadiazole

: 138129-06-3
{3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid 4-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / pyridine, methanesulfonyl chloride / CH₂Cl₂ / Ambient temperature

2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 30 min

With pyridine; sodium hydride; methanesulfonyl chloride; In dichloromethane;
DOI:10.1021/jm00081a006

Reference yield:

: 138128-75-3
ethyl 3-(2-chlorophenyl)-1,2,4-thiadiazole-5-carboxylate

: 138129-06-3
{3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid 4-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / lithium tri-tert-butoxyaluminohydride / tetrahydrofuran / 0.5 h

2: 58 percent / pyridine, methanesulfonyl chloride / CH₂Cl₂ / Ambient temperature

3: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 30 min

With pyridine; lithium tri(t-butoxy)aluminum hydride; sodium hydride; methanesulfonyl chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00081a006

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 138129-06-3
{3-[3-(2-Chloro-phenyl)-[1,2,4]thiadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid 4-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 42 percent / NaI, triethylamine / dimethylformamide / 3 h

2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 30 min

With sodium hydride; triethylamine; sodium iodide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00081a006