tert-butyl (2-(1-fluoro-2-(p-tolyl)ethyl)benzoyl)(quinolin-8-yl)carbamate

Base Information

Chemical Name:tert-butyl (2-(1-fluoro-2-(p-tolyl)ethyl)benzoyl)(quinolin-8-yl)carbamate
CAS No.:1578268-85-5
Molecular Formula:C₃₀H₂₉FN₂O₃
Molecular Weight:484.57
Hs Code.:

Synonyms:tert-butyl (2-(1-fluoro-2-(p-tolyl)ethyl)benzoyl)(quinolin-8-yl)carbamate

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Chemical Property of tert-butyl (2-(1-fluoro-2-(p-tolyl)ethyl)benzoyl)(quinolin-8-yl)carbamate

Chemical Property:

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Technology Process of tert-butyl (2-(1-fluoro-2-(p-tolyl)ethyl)benzoyl)(quinolin-8-yl)carbamate

There total 4 articles about tert-butyl (2-(1-fluoro-2-(p-tolyl)ethyl)benzoyl)(quinolin-8-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1578268-79-7
2-(1-fluoro-2-(p-tolyl)ethyl)-N-(quinolin-8-yl)benzamide

: 1578268-85-5
tert-butyl (2-(1-fluoro-2-(p-tolyl)ethyl)benzoyl)(quinolin-8-yl)carbamate

Guidance literature:: With dmap; In dichloromethane;
DOI:10.1021/ja412881j

Reference yield:

: 1578268-89-9
2‐ethenyl‐N‐(quinolin‐8‐yl)benzamide

: 1578268-85-5
tert-butyl (2-(1-fluoro-2-(p-tolyl)ethyl)benzoyl)(quinolin-8-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 4-tert-Butylcatechol; Selectfluor; palladium diacetate; Bis(2-ethylhexyl)phosphoric acid; 4,4'-di-tert-butyl-2,2'-bipyridine / water; dichloromethane / 20 °C / Inert atmosphere

2: dmap / dichloromethane

With dmap; Bis(2-ethylhexyl)phosphoric acid; 4-tert-Butylcatechol; palladium diacetate; Selectfluor; 4,4'-di-tert-butyl-2,2'-bipyridine; In dichloromethane; water;
DOI:10.1021/ja412881j

Reference yield:

: 27326-43-8
2-vinylbenzoic acid

: 1578268-85-5
tert-butyl (2-(1-fluoro-2-(p-tolyl)ethyl)benzoyl)(quinolin-8-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h

2: N-ethyl-N,N-diisopropylamine / dichloromethane

3: 4-tert-Butylcatechol; Selectfluor; palladium diacetate; Bis(2-ethylhexyl)phosphoric acid; 4,4'-di-tert-butyl-2,2'-bipyridine / water; dichloromethane / 20 °C / Inert atmosphere

4: dmap / dichloromethane

With dmap; oxalyl dichloride; Bis(2-ethylhexyl)phosphoric acid; 4-tert-Butylcatechol; palladium diacetate; Selectfluor; N-ethyl-N,N-diisopropylamine; 4,4'-di-tert-butyl-2,2'-bipyridine; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja412881j