Technology Process of 2-(1-fluoro-2-(p-tolyl)ethyl)benzoic acid
There total 5 articles about 2-(1-fluoro-2-(p-tolyl)ethyl)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dihydrogen peroxide; lithium hydroxide;
In
tetrahydrofuran; water;
at 20 ℃;
for 5h;
DOI:10.1021/ja412881j
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 4-tert-Butylcatechol; Selectfluor; palladium diacetate; Bis(2-ethylhexyl)phosphoric acid; 4,4'-di-tert-butyl-2,2'-bipyridine / water; dichloromethane / 20 °C / Inert atmosphere
2: dmap / dichloromethane
3: lithium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 5 h / 20 °C
With
dmap; Bis(2-ethylhexyl)phosphoric acid; 4-tert-Butylcatechol; dihydrogen peroxide; palladium diacetate; Selectfluor; 4,4'-di-tert-butyl-2,2'-bipyridine; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ja412881j
- Guidance literature:
-
Multi-step reaction with 5 steps
1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h
2: N-ethyl-N,N-diisopropylamine / dichloromethane
3: 4-tert-Butylcatechol; Selectfluor; palladium diacetate; Bis(2-ethylhexyl)phosphoric acid; 4,4'-di-tert-butyl-2,2'-bipyridine / water; dichloromethane / 20 °C / Inert atmosphere
4: dmap / dichloromethane
5: lithium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 5 h / 20 °C
With
dmap; oxalyl dichloride; Bis(2-ethylhexyl)phosphoric acid; 4-tert-Butylcatechol; dihydrogen peroxide; palladium diacetate; Selectfluor; N-ethyl-N,N-diisopropylamine; 4,4'-di-tert-butyl-2,2'-bipyridine; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja412881j
