C₃₈H₅₀N₂O₉Si

Base Information

• Chemical Name: C₃₈H₅₀N₂O₉Si
• CAS No.: 914933-51-0
• Molecular Formula: C₃₈H₅₀N₂O₉Si
• Molecular Weight: 706.909
• Mol file: 914933-51-0.mol

Synonyms:C₃₈H₅₀N₂O₉Si

Chemical Property of C₃₈H₅₀N₂O₉Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₈H₅₀N₂O₉Si

There total 9 articles about C₃₈H₅₀N₂O₉Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C35H46N2O9Si (947771-36-0) + 2,2-dimethoxy-propane (77-76-9) → C38H50N2O9Si (914933-51-0)

Guidance literature:

With toluene-4-sulfonic acid; at 20 ℃; for 2h;

DOI:10.1002/chem.200700033

Reference yield:

3-{2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazol-4-yl}-5-(5,6-dimethoxy-3,5,6-trimethyl-[1,4]dioxan-2-yl)-4,5-dihydro-isoxazole (914933-35-0) → C38H50N2O9Si (914933-51-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 61 percent / boric acid; hydrogen / Raney nickel / ethanol; H₂O / 3 h / 20 °C

2: diethylmethoxyborane; NaBH₄ / tetrahydrofuran / 16 h / -78 °C

3: 89 percent / para-toluenesulfonic acid / 2 h / 20 °C

With sodium tetrahydroborate; diethyl methoxy borane; hydrogen; boric acid; toluene-4-sulfonic acid; nickel; In tetrahydrofuran; ethanol; water;

DOI:10.1002/chem.200700033

Reference yield:

(2S,3R,5S,6S)-5,6-dimethoxy-3,5,6-trimethyl-[1,4]dioxane-2-carbaldehyde (914933-47-4) → C38H50N2O9Si (914933-51-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 100 percent / KHMDS / tetrahydrofuran / -78 - 20 °C

2.1: N-chlorosuccinimide; pyridine / CH₂Cl₂ / 20 °C

2.2: 60 percent / Cs₂CO₃ / 1,2-dimethoxy-ethane / 20 °C

3.1: 61 percent / H₂; aq. B(OH)3 / Raney nickel / ethanol

4.1: Et₂BOMe; NaBH₄ / tetrahydrofuran / -78 °C

5.1: TsOH

With pyridine; sodium tetrahydroborate; N-chloro-succinimide; diethyl methoxy borane; hydrogen; boric acid; potassium hexamethylsilazane; toluene-4-sulfonic acid; nickel; In tetrahydrofuran; ethanol; dichloromethane; 1.1: Wittig reaction;

DOI:10.1002/anie.200602050

upstream raw materials:

C₃₅H₄₆N₂O₉Si

2,2-dimethoxy-propane

3-{2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazol-4-yl}-5-(5,6-dimethoxy-3,5,6-trimethyl-[1,4]dioxan-2-yl)-4,5-dihydro-isoxazole

(R)-1-{2-[(S)-(tert-butyldiphenylsilyloxy)oxazol-5-ylmethyl]oxazol-4-yl}-3-[(2R,3R,5S,6S)-5,6-dimethoxy-3,5,6-trimethyl-[1,4]dioxan-2-yl]-3-hydroxypropan-1-one