2,3,4-trimethoxy-5-[3-methyl-(3-phenylpropyl)sulfamoyl]benzoic acid

Base Information

• Chemical Name: 2,3,4-trimethoxy-5-[3-methyl-(3-phenylpropyl)sulfamoyl]benzoic acid
• CAS No.: 936847-34-6
• Molecular Formula: C₂₀H₂₅NO₇S
• Molecular Weight: 423.487
• Mol file: 936847-34-6.mol

Synonyms:2,3,4-trimethoxy-5-[3-methyl-(3-phenylpropyl)sulfamoyl]benzoic acid

Chemical Property of 2,3,4-trimethoxy-5-[3-methyl-(3-phenylpropyl)sulfamoyl]benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2,3,4-trimethoxy-5-[3-methyl-(3-phenylpropyl)sulfamoyl]benzoic acid

There total 1 articles about 2,3,4-trimethoxy-5-[3-methyl-(3-phenylpropyl)sulfamoyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,4-trimethoxy-5-[methyl-(3-phenyl-propyl)-sulfamoyl]-benzoic acid methyl ester → 2,3,4-trimethoxy-5-[3-methyl-(3-phenylpropyl)sulfamoyl]benzoic acid (936847-34-6)

Guidance literature:

With potassium hydroxide; In methanol; at 60 ℃; for 3h;

DOI:10.1021/jm061400l

Reference yield: 85.0%

2,3,4-trimethoxy-5-[3-methyl-(3-phenylpropyl)sulfamoyl]benzoic acid (936847-34-6) + N-phenethyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (760123-89-5) → 2-{2,3,4-trimethoxy-5-[methyl-(3-phenylpropyl)sulfamoyl]benzoyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonic acid phenethylamide (936847-35-7)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; tert-butyl alcohol; at 20 ℃; for 3h;

DOI:10.1021/jm061400l

Reference yield:

2,3,4-trimethoxy-5-[3-methyl-(3-phenylpropyl)sulfamoyl]benzoic acid (936847-34-6) → 2-{2,3,4-trihydroxy-5-[methyl-(3-phenyl-propyl)-sulfamoyl]-benzoyl}-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid phenethyl-amide

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / EDAC; DIPEA / 2-methyl-propan-2-ol; CH₂Cl₂ / 3 h / 20 °C

2: 70 percent / BBr₃ / CH₂Cl₂ / 1 h / -78 - -20 °C

With boron tribromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; tert-butyl alcohol;

DOI:10.1021/jm061400l

Downstream raw materials:

2-{2,3,4-trimethoxy-5-[methyl-(3-phenylpropyl)sulfamoyl]benzoyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonic acid phenethylamide