2-{2,3,4-trimethoxy-5-[methyl-(3-phenylpropyl)sulfamoyl]benzoyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonic acid phenethylamide

Base Information

Chemical Name:2-{2,3,4-trimethoxy-5-[methyl-(3-phenylpropyl)sulfamoyl]benzoyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonic acid phenethylamide
CAS No.:936847-35-7
Molecular Formula:C₃₇H₄₃N₃O₈S₂
Molecular Weight:721.896
Hs Code.:

Synonyms:2-{2,3,4-trimethoxy-5-[methyl-(3-phenylpropyl)sulfamoyl]benzoyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonic acid phenethylamide

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Chemical Property of 2-{2,3,4-trimethoxy-5-[methyl-(3-phenylpropyl)sulfamoyl]benzoyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonic acid phenethylamide

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Technology Process of 2-{2,3,4-trimethoxy-5-[methyl-(3-phenylpropyl)sulfamoyl]benzoyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonic acid phenethylamide

There total 5 articles about 2-{2,3,4-trimethoxy-5-[methyl-(3-phenylpropyl)sulfamoyl]benzoyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonic acid phenethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 936847-34-6
2,3,4-trimethoxy-5-[3-methyl-(3-phenylpropyl)sulfamoyl]benzoic acid

: 760123-89-5
N-phenethyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide

: 936847-35-7
2-{2,3,4-trimethoxy-5-[methyl-(3-phenylpropyl)sulfamoyl]benzoyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonic acid phenethylamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; tert-butyl alcohol; at 20 ℃; for 3h;
DOI:10.1021/jm061400l

Reference yield:

: 2,3,4-trimethoxy-5-[methyl-(3-phenyl-propyl)-sulfamoyl]-benzoic acid methyl ester

: 936847-35-7
2-{2,3,4-trimethoxy-5-[methyl-(3-phenylpropyl)sulfamoyl]benzoyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonic acid phenethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 0.95 g / aq. KOH / methanol / 3 h / 60 °C

2: 85 percent / EDAC; DIPEA / 2-methyl-propan-2-ol; CH₂Cl₂ / 3 h / 20 °C

With potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jm061400l

Reference yield:

: 936847-38-0
N-phenethyl-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide

: 936847-35-7
2-{2,3,4-trimethoxy-5-[methyl-(3-phenylpropyl)sulfamoyl]benzoyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonic acid phenethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / potassium carbonate; methanol / 0.33 h / 20 °C

2: 85 percent / EDAC; DIPEA / 2-methyl-propan-2-ol; CH₂Cl₂ / 3 h / 20 °C

With methanol; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; tert-butyl alcohol;
DOI:10.1021/jm061400l