3-[2-[(3-methylphenyl)amino]-4-(4-pyridinyl)-1,3-thiazol-5-yl]-1-propanol

Base Information

Chemical Name:3-[2-[(3-methylphenyl)amino]-4-(4-pyridinyl)-1,3-thiazol-5-yl]-1-propanol
CAS No.:1187668-96-7
Molecular Formula:C₁₈H₁₉N₃OS
Molecular Weight:325.434
Hs Code.:

Synonyms:3-[2-[(3-methylphenyl)amino]-4-(4-pyridinyl)-1,3-thiazol-5-yl]-1-propanol

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Chemical Property of 3-[2-[(3-methylphenyl)amino]-4-(4-pyridinyl)-1,3-thiazol-5-yl]-1-propanol

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Technology Process of 3-[2-[(3-methylphenyl)amino]-4-(4-pyridinyl)-1,3-thiazol-5-yl]-1-propanol

There total 10 articles about 3-[2-[(3-methylphenyl)amino]-4-(4-pyridinyl)-1,3-thiazol-5-yl]-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1187668-99-0
3-[2-[(3-methylphenyl)amino]-4-(4-pyridinyl)-1,3-thiazol-5-yl]propanoic acid

: 1187668-96-7
3-[2-[(3-methylphenyl)amino]-4-(4-pyridinyl)-1,3-thiazol-5-yl]-1-propanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/jm901457w

Reference yield:

: 1122-54-9
methyl (4-pyridyl) ketone

: 1187668-96-7
3-[2-[(3-methylphenyl)amino]-4-(4-pyridinyl)-1,3-thiazol-5-yl]-1-propanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen bromide; bromine; acetic acid / 0 - 75 °C

2.1: ethanol / 3 h / Heating; Reflux

2.2: 2 h / 20 °C / pH ~ 8

3.1: triethylamine / tetrahydrofuran; water / 1 h / 130 °C

4.1: manganese(IV) oxide / benzene / 2 h / 80 °C

5.1: dichloromethane / 48 h / 20 °C

6.1: hydrogen / palladium on activated charcoal / ethanol; ethyl acetate / 16 h / 20 °C / 3102.97 Torr

7.1: methanol; water; sodium hydroxide / 6 h / 20 °C

7.2: 16 h / 5 °C / pH 6

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

8.2: 20 °C

With methanol; manganese(IV) oxide; lithium aluminium tetrahydride; water; hydrogen bromide; hydrogen; bromine; acetic acid; triethylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; benzene; 2.1: Hantzsch thiazole synthesis;

Reference yield:

: 315702-99-9
N-(3-methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

: 1187668-96-7
3-[2-[(3-methylphenyl)amino]-4-(4-pyridinyl)-1,3-thiazol-5-yl]-1-propanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / tetrahydrofuran; water / 1 h / 130 °C

2.1: manganese(IV) oxide / benzene / 2 h / 80 °C

3.1: dichloromethane / 48 h / 20 °C

4.1: hydrogen / palladium on activated charcoal / ethanol; ethyl acetate / 16 h / 20 °C / 3102.97 Torr

5.1: methanol; water; sodium hydroxide / 6 h / 20 °C

5.2: 16 h / 5 °C / pH 6

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

6.2: 20 °C

With methanol; manganese(IV) oxide; lithium aluminium tetrahydride; water; hydrogen; triethylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; benzene;