4-(pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine

Base Information

Chemical Name:4-(pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine
CAS No.:315702-99-9
Molecular Formula:C15H13N3S
Molecular Weight:267.354
Hs Code.:
European Community (EC) Number:631-141-1
DSSTox Substance ID:DTXSID90351598
Nikkaji Number:J3.666.560B
Wikidata:Q27216266
ChEMBL ID:CHEMBL565269
Mol file:315702-99-9.mol

Synonyms:STF 62247;STF-62247;STF62247

Suppliers and Price of 4-(pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Autophagy Inducer, STF-62247
25mg
$ 275.00

Sigma-Aldrich
Autophagy Inducer, STF-62247
10mg
$ 85.65

Sigma-Aldrich
STF-62247 ≥98% (HPLC), solid
5mg
$ 144.00

DC Chemicals
STF-62247 >98%
100 mg
$ 450.00

DC Chemicals
STF-62247 >98%
1 g
$ 1450.00

Cayman Chemical
STF-62247 ≥98%
10mg
$ 130.00

Cayman Chemical
STF-62247 ≥98%
25mg
$ 285.00

Cayman Chemical
STF-62247 ≥98%
5mg
$ 75.00

Cayman Chemical
STF-62247 ≥98%
1mg
$ 17.00

Axon Medchem
STF62247 99%
10 mg
$ 93.50

Total 26 raw suppliers

Chemical Property of 4-(pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine

Chemical Property:

Vapor Pressure:4.15E-08mmHg at 25°C
Melting Point:158-160℃
Boiling Point:444.8°C at 760 mmHg
Flash Point:222.8°C
PSA：66.05000
Density:1.255g/cm³
LogP:4.33010
Storage Temp.:room temp
Solubility.:DMSO: soluble26mg/mL
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:267.08301860
Heavy Atom Count:19
Complexity:281

Purity/Quality:

99%, ^*data from raw suppliers

Autophagy Inducer, STF-62247 ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-36
Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3
Description STF-62247 (315702-99-9) specifically induces autophagic cell death in VHL (von Hippel-Lindau)-deficient renal carcinoma cells both in vitro (IC50=625 nM) and in vivo. Renal cell carcinoma cell lines were radiosensitized by induction of autophagy following treatment with STF-62247. Cell permeable
Uses Autophagy Inducer, STF-62247 is selectively kills RCC cells that have lost VHL tumor suppressor activity.

Technology Process of 4-(pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine

There total 3 articles about 4-(pyridin-4-yl)-N-(m-tolyl)thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 621-40-9
(3-methylphenyl)thiourea

: 5349-17-7
4-bromoacetylpyridine hydrobromide

: 315702-99-9
N-(3-methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

Guidance literature:: In ethanol; for 1h; Reflux;
DOI:10.1021/jm901457w

Reference yield:

: 1122-54-9
methyl (4-pyridyl) ketone

: 315702-99-9
N-(3-methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen bromide; bromine; acetic acid / 0 - 75 °C

2.1: ethanol / 3 h / Heating; Reflux

2.2: 2 h / 20 °C / pH ~ 8

With hydrogen bromide; bromine; acetic acid; In ethanol; 2.1: Hantzsch thiazole synthesis;

Reference yield:

: 108-44-1
1-amino-3-methylbenzene

: 315702-99-9
N-(3-methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzoyl chloride / acetone / Heating; Reflux

1.2: 20 °C / Heating; Reflux; Cooling with ice

1.3: 80 °C / pH 10 / Cooling with ice

2.1: ethanol / 3 h / Heating; Reflux

2.2: 2 h / 20 °C / pH ~ 8

With benzoyl chloride; In ethanol; acetone; 2.1: Hantzsch thiazole synthesis;