2-Methyl-propane-2-sulfinic acid ((1R,3R)-1,3-dimethyl-cyclohexyl)-amide

Base Information

• Chemical Name: 2-Methyl-propane-2-sulfinic acid ((1R,3R)-1,3-dimethyl-cyclohexyl)-amide
• CAS No.: 700827-88-9
• Molecular Formula: C₁₂H₂₅NOS
• Molecular Weight: 231.403

Synonyms:2-Methyl-propane-2-sulfinic acid ((1R,3R)-1,3-dimethyl-cyclohexyl)-amide

Chemical Property of 2-Methyl-propane-2-sulfinic acid ((1R,3R)-1,3-dimethyl-cyclohexyl)-amide

Chemical Property:

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Technology Process of 2-Methyl-propane-2-sulfinic acid ((1R,3R)-1,3-dimethyl-cyclohexyl)-amide

There total 2 articles about 2-Methyl-propane-2-sulfinic acid ((1R,3R)-1,3-dimethyl-cyclohexyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methylmagnesium bromide (75-16-1) + 2-Methyl-propane-2-sulfinic acid [(R)-3-methyl-cyclohex-(Z)-ylidene]-amide (700827-83-4) → 2-Methyl-propane-2-sulfinic acid ((1R,3R)-1,3-dimethyl-cyclohexyl)-amide (700827-88-9)

Guidance literature:

In diethyl ether; at -78 - 25 ℃;

DOI:10.1021/ol0495220

Reference yield:

(3R)-3-methylcyclohexanone (13368-65-5) → 2-Methyl-propane-2-sulfinic acid ((1R,3R)-1,3-dimethyl-cyclohexyl)-amide (700827-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / Ti(OEt)4 / tetrahydrofuran; propan-2-ol / 2 h / 20 °C

2: 78 percent / diethyl ether / -78 - 25 °C

With titanium(IV) tetraethanolate; In tetrahydrofuran; diethyl ether; isopropyl alcohol;

DOI:10.1021/ol0495220

Reference yield: 50.0%

2-Methyl-propane-2-sulfinic acid ((1R,3R)-1,3-dimethyl-cyclohexyl)-amide (700827-88-9) → (R,R)-1,3-dimethylcyclohexylamine hydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; for 0.5h;

DOI:10.1021/ol0495220

upstream raw materials:

methylmagnesium bromide

2-Methyl-propane-2-sulfinic acid [(R)-3-methyl-cyclohex-(Z)-ylidene]-amide

(3R)-3-methylcyclohexanone

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