1-(4-(4-(2-bromoacetyl)piperazin-1-yl)-2,3-dihydro-1H-inden-1-yl)-N-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Base Information

Chemical Name:1-(4-(4-(2-bromoacetyl)piperazin-1-yl)-2,3-dihydro-1H-inden-1-yl)-N-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
CAS No.:1253417-27-4
Molecular Formula:C₂₇H₂₆BrClN₄O₃
Molecular Weight:569.885
Hs Code.:

Synonyms:1-(4-(4-(2-bromoacetyl)piperazin-1-yl)-2,3-dihydro-1H-inden-1-yl)-N-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Chemical Property of 1-(4-(4-(2-bromoacetyl)piperazin-1-yl)-2,3-dihydro-1H-inden-1-yl)-N-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Technology Process of 1-(4-(4-(2-bromoacetyl)piperazin-1-yl)-2,3-dihydro-1H-inden-1-yl)-N-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

There total 2 articles about 1-(4-(4-(2-bromoacetyl)piperazin-1-yl)-2,3-dihydro-1H-inden-1-yl)-N-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1253416-56-6
N-(4-chlorophenyl)-2-oxo-1-(4-(piperazin-1-yl)-2,3-dihydro-1H-inden-1-yl)-1,2-dihydropyridine-3-carboxamide

: 598-21-0
2-Bromoacetyl bromide

: 1253417-27-4
1-(4-(4-(2-bromoacetyl)piperazin-1-yl)-2,3-dihydro-1H-inden-1-yl)-N-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;

Reference yield:

: 1253416-30-6
tert-butyl 4-(1-(3-(4-chlorophenylcarbamoyl)-2-oxopyridin-1(2H)-yl)-2,3-dihydro-1H-inden-4-yl)piperazine-1-carboxylate

: 1253417-27-4
1-(4-(4-(2-bromoacetyl)piperazin-1-yl)-2,3-dihydro-1H-inden-1-yl)-N-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

Reference yield: 45.0%

: 1253417-27-4
1-(4-(4-(2-bromoacetyl)piperazin-1-yl)-2,3-dihydro-1H-inden-1-yl)-N-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

: 139115-92-7
tert-butyl 2-(2-(2-hydroxyethoxy)ethoxy)ethylcarbamate

: 1253416-67-9
tert-butyl 2-(2-(2-(2-(4-(1-(3-(4-chlorophenylcarbamoyl)-2-oxopyridin-1(2H)-yl)-2,3-dihydro-1H-inden-4-yl)piperazin-1-yl)-2-oxoethoxy)ethoxy)ethoxy)ethylcarbamate

Guidance literature:: tert-butyl 2-(2-(2-hydroxyethoxy)ethoxy)ethylcarbamate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 - 60 ℃;

1-(4-(4-(2-bromoacetyl)piperazin-1-yl)-2,3-dihydro-1H-inden-1-yl)-N-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h;