tert-butyl 2-(2-(2-(2-(4-(1-(3-(4-chlorophenylcarbamoyl)-2-oxopyridin-1(2H)-yl)-2,3-dihydro-1H-inden-4-yl)piperazin-1-yl)-2-oxoethoxy)ethoxy)ethoxy)ethylcarbamate

Base Information

Chemical Name:tert-butyl 2-(2-(2-(2-(4-(1-(3-(4-chlorophenylcarbamoyl)-2-oxopyridin-1(2H)-yl)-2,3-dihydro-1H-inden-4-yl)piperazin-1-yl)-2-oxoethoxy)ethoxy)ethoxy)ethylcarbamate
CAS No.:1253416-67-9
Molecular Formula:C₃₈H₄₈ClN₅O₈
Molecular Weight:738.281
Hs Code.:

tert-butyl 2-(2-(2-(2-(4-(1-(3-(4-chlorophenylcarbamoyl)-2-oxopyridin-1(2H)-yl)-2,3-dihydro-1H-inden-4-yl)piperazin-1-yl)-2-oxoethoxy)ethoxy)ethoxy)ethylcarbamate

Synonyms:tert-butyl 2-(2-(2-(2-(4-(1-(3-(4-chlorophenylcarbamoyl)-2-oxopyridin-1(2H)-yl)-2,3-dihydro-1H-inden-4-yl)piperazin-1-yl)-2-oxoethoxy)ethoxy)ethoxy)ethylcarbamate

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Chemical Property of tert-butyl 2-(2-(2-(2-(4-(1-(3-(4-chlorophenylcarbamoyl)-2-oxopyridin-1(2H)-yl)-2,3-dihydro-1H-inden-4-yl)piperazin-1-yl)-2-oxoethoxy)ethoxy)ethoxy)ethylcarbamate

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Technology Process of tert-butyl 2-(2-(2-(2-(4-(1-(3-(4-chlorophenylcarbamoyl)-2-oxopyridin-1(2H)-yl)-2,3-dihydro-1H-inden-4-yl)piperazin-1-yl)-2-oxoethoxy)ethoxy)ethoxy)ethylcarbamate

There total 3 articles about tert-butyl 2-(2-(2-(2-(4-(1-(3-(4-chlorophenylcarbamoyl)-2-oxopyridin-1(2H)-yl)-2,3-dihydro-1H-inden-4-yl)piperazin-1-yl)-2-oxoethoxy)ethoxy)ethoxy)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1253417-27-4
1-(4-(4-(2-bromoacetyl)piperazin-1-yl)-2,3-dihydro-1H-inden-1-yl)-N-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

: 139115-92-7
tert-butyl 2-(2-(2-hydroxyethoxy)ethoxy)ethylcarbamate

: 1253416-67-9
tert-butyl 2-(2-(2-(2-(4-(1-(3-(4-chlorophenylcarbamoyl)-2-oxopyridin-1(2H)-yl)-2,3-dihydro-1H-inden-4-yl)piperazin-1-yl)-2-oxoethoxy)ethoxy)ethoxy)ethylcarbamate

Guidance literature:: tert-butyl 2-(2-(2-hydroxyethoxy)ethoxy)ethylcarbamate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 - 60 ℃;

1-(4-(4-(2-bromoacetyl)piperazin-1-yl)-2,3-dihydro-1H-inden-1-yl)-N-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h;

Reference yield:

: 1253416-30-6
tert-butyl 4-(1-(3-(4-chlorophenylcarbamoyl)-2-oxopyridin-1(2H)-yl)-2,3-dihydro-1H-inden-4-yl)piperazine-1-carboxylate

: 1253416-67-9
tert-butyl 2-(2-(2-(2-(4-(1-(3-(4-chlorophenylcarbamoyl)-2-oxopyridin-1(2H)-yl)-2,3-dihydro-1H-inden-4-yl)piperazin-1-yl)-2-oxoethoxy)ethoxy)ethoxy)ethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 - 60 °C

3.2: 1 h / 20 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1253416-56-6
N-(4-chlorophenyl)-2-oxo-1-(4-(piperazin-1-yl)-2,3-dihydro-1H-inden-1-yl)-1,2-dihydropyridine-3-carboxamide

: 1253416-67-9
tert-butyl 2-(2-(2-(2-(4-(1-(3-(4-chlorophenylcarbamoyl)-2-oxopyridin-1(2H)-yl)-2,3-dihydro-1H-inden-4-yl)piperazin-1-yl)-2-oxoethoxy)ethoxy)ethoxy)ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 - 60 °C

2.2: 1 h / 20 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;