(3R,5S)-4-(4-chlorobenzoyl)-3,5,7-trimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine

Base Information

Chemical Name:(3R,5S)-4-(4-chlorobenzoyl)-3,5,7-trimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine
CAS No.:1345731-49-8
Molecular Formula:C₁₉H₂₀ClNO₂
Molecular Weight:329.826
Hs Code.:

Synonyms:(3R,5S)-4-(4-chlorobenzoyl)-3,5,7-trimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine

Suppliers and Price of (3R,5S)-4-(4-chlorobenzoyl)-3,5,7-trimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,5S)-4-(4-chlorobenzoyl)-3,5,7-trimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,5S)-4-(4-chlorobenzoyl)-3,5,7-trimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine

There total 4 articles about (3R,5S)-4-(4-chlorobenzoyl)-3,5,7-trimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1345731-70-5
(3R,5S)-3,5,7-trimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine

: 122-01-0
4-chloro-benzoyl chloride

: 1345731-49-8
(3R,5S)-4-(4-chlorobenzoyl)-3,5,7-trimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2011.08.093

Reference yield:

: 1345731-68-1
tert-butyl [(R)-2-(2-acetyl-4-methylphenoxy)-1-methylethyl]carbamate

: 1345731-49-8
(3R,5S)-4-(4-chlorobenzoyl)-3,5,7-trimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: sodium tetrahydroborate / ethanol / 0 - 20 °C

3: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C

With sodium tetrahydroborate; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.08.093

Reference yield:

: 1345731-69-2
(R)-3,5,7-trimethyl-2,3-dihydro-1,4-benzoxazepine

: 1345731-49-8
(3R,5S)-4-(4-chlorobenzoyl)-3,5,7-trimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 0 - 20 °C

2: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C

With sodium tetrahydroborate; sodium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2011.08.093