(R)-benzyl 3-((2-aminophenyl)(cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate

Base Information

Chemical Name:(R)-benzyl 3-((2-aminophenyl)(cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate
CAS No.:1246926-37-3
Molecular Formula:C₂₄H₂₈F₃N₃O₃
Molecular Weight:463.5
Hs Code.:

Synonyms:(R)-benzyl 3-((2-aminophenyl)(cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate

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Chemical Property of (R)-benzyl 3-((2-aminophenyl)(cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate

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Technology Process of (R)-benzyl 3-((2-aminophenyl)(cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate

There total 1 articles about (R)-benzyl 3-((2-aminophenyl)(cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1246926-36-2
(R)-benzyl 3-((2-(tert-butoxycarbonylamino)phenyl)(cyclohexyl)amino)-2-(2,2,2-trifluoroacetamide) propionate

: 1246926-37-3
(R)-benzyl 3-((2-aminophenyl)(cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate

Guidance literature:: (R)-benzyl 3-((2-(tert-butoxycarbonylamino)phenyl)(cyclohexyl)amino)-2-(2,2,2-trifluoroacetamide) propionate; With hydrogenchloride; In water; at 65 ℃; for 4.5h;

With sodium hydrogencarbonate; In water; pH=10;

Reference yield:

: 1246926-37-3
(R)-benzyl 3-((2-aminophenyl)(cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate

: 1246926-43-1
(R)-N-(1-cyclohexyl-4-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-4-methylbenzenesulfonamide

Guidance literature:: 5%-palladium/activated carbon; In water; toluene; at 20 ℃; for 13h; Inert atmosphere;

Reference yield:

: 1246926-37-3
(R)-benzyl 3-((2-aminophenyl)(cyclohexyl)amino)-2-(2,2,2-trifluoroacetamido)propionate

: 209219-38-5
(R)-(-)-3-[3-(1-tert-butylcarbonylmethyl-2-oxo-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]ureido]benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 5%-palladium/activated carbon / toluene; water / 13 h / 20 °C / Inert atmosphere

2: hydrogen bromide / 1 h / Reflux

3: triethylamine / dimethyl sulfoxide / 2 h / 60 °C

With hydrogen bromide; triethylamine; 5%-palladium/activated carbon; In water; dimethyl sulfoxide; toluene;