4,7-dimethoxy-7-(4-methoxyphenyl)-9-(trimethylsilyl)-1,4-diphenylnona-2,5,8-triyn-1-one

Base Information

• Chemical Name: 4,7-dimethoxy-7-(4-methoxyphenyl)-9-(trimethylsilyl)-1,4-diphenylnona-2,5,8-triyn-1-one
• CAS No.: 945393-00-0
• Molecular Formula: C₃₃H₃₂O₄Si
• Molecular Weight: 520.7
• Mol file: 945393-00-0.mol

Synonyms:4,7-dimethoxy-7-(4-methoxyphenyl)-9-(trimethylsilyl)-1,4-diphenylnona-2,5,8-triyn-1-one

Chemical Property of 4,7-dimethoxy-7-(4-methoxyphenyl)-9-(trimethylsilyl)-1,4-diphenylnona-2,5,8-triyn-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,7-dimethoxy-7-(4-methoxyphenyl)-9-(trimethylsilyl)-1,4-diphenylnona-2,5,8-triyn-1-one

There total 1 articles about 4,7-dimethoxy-7-(4-methoxyphenyl)-9-(trimethylsilyl)-1,4-diphenylnona-2,5,8-triyn-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

1,4-diphenyl-but-2-yne-1,4-dione (1087-09-8) + methyl iodide (74-88-4) + 1-trimethylsilyl-3-(4-methoxyphenyl)-3-methoxypenta-1,4-diyne (801287-33-2) → 4,7-dimethoxy-7-(4-methoxyphenyl)-9-(trimethylsilyl)-1,4-diphenylnona-2,5,8-triyn-1-one (945393-00-0)

Guidance literature:

1-trimethylsilyl-3-(4-methoxyphenyl)-3-methoxypenta-1,4-diyne; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

1,4-diphenyl-but-2-yne-1,4-dione; In tetrahydrofuran; hexane; at -25 ℃; for 3h;

methyl iodide; In tetrahydrofuran; hexane; dimethyl sulfoxide; at 20 ℃; for 17h; Further stages.;

DOI:10.1002/chem.200601191

Reference yield:

4,7-dimethoxy-7-(4-methoxyphenyl)-9-(trimethylsilyl)-1,4-diphenylnona-2,5,8-triyn-1-one (945393-00-0) + 1-(trimethylsilyl)-3-(pyridin-4-yl)penta-1,4-diyn-3-ol (945393-01-1) → C46H47NO5Si2

Guidance literature:

1-(trimethylsilyl)-3-(pyridin-4-yl)penta-1,4-diyn-3-ol; With n-butyllithium; In tetrahydrofuran; hexane; at -20 ℃; for 0.333333h;

4,7-dimethoxy-7-(4-methoxyphenyl)-9-(trimethylsilyl)-1,4-diphenylnona-2,5,8-triyn-1-one; In tetrahydrofuran; hexane; at -20 - 20 ℃; for 4h; Further stages.;

DOI:10.1002/chem.200601191

Reference yield:

4,7-dimethoxy-7-(4-methoxyphenyl)-9-(trimethylsilyl)-1,4-diphenylnona-2,5,8-triyn-1-one (945393-00-0) → 9,12-dimethoxy-12-(4-methoxyphenyl)-6,9-diphenyl-3-(pyridin-4-yl)tetradeca-1,4,7,10,13-pentayne-3,6-diol (945393-02-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -20 °C

1.2: tetrahydrofuran; hexane / 4 h / -20 - 20 °C

2.1: 8.131 g / tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; hexane;

DOI:10.1002/chem.200601191

upstream raw materials:

1,4-diphenyl-but-2-yne-1,4-dione

methyl iodide

1-trimethylsilyl-3-(4-methoxyphenyl)-3-methoxypenta-1,4-diyne

Downstream raw materials:

9,12-dimethoxy-12-(4-methoxyphenyl)-6,9-diphenyl-3-(pyridin-4-yl)tetradeca-1,4,7,10,13-pentayne-3,6-diol