(Z)-2-bromo-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide

Base Information

• Chemical Name: (Z)-2-bromo-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide
• CAS No.: 285133-48-4
• Molecular Formula: C₁₇H₁₉BrN₂O₄S
• Molecular Weight: 427.319
• Mol file: 285133-48-4.mol

Synonyms:(Z)-2-bromo-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide

Chemical Property of (Z)-2-bromo-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (Z)-2-bromo-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide

There total 3 articles about (Z)-2-bromo-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(Z)-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide (204690-22-2) → (Z)-2-bromo-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide (285133-48-4)

Guidance literature:

With bromine; In tetrachloromethane; Reflux;

DOI:10.1016/j.tet.2010.06.057

Reference yield: 66.0%

(Z)-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide (204690-22-2) → (Z)-2-bromo-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide (285133-48-4) + {5-Bromo-2-[1-bromo-1-phenethylcarbamoyl-meth-(Z)-ylidene]-4-oxo-thiazolidin-5-yl}-acetic acid ethyl ester

Guidance literature:

With bromine; In ethanol; at 20 ℃; for 0.166667h;

Reference yield:

(Z)-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide (204690-22-2) → (E)-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)-2-bromoethanamide + (Z)-2-bromo-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide (285133-48-4)

Guidance literature:

(Z)-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide; With bromine; In tetrachloromethane; for 0.666667h; Heating;

In dimethylsulfoxide-d6; for 240h; Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(01)00496-3

upstream raw materials:

(Z)-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide

Downstream raw materials:

(2Z,5Z)-(5-Ethoxycarbonylmethylidene-4-oxothiazolidin-2-ylidene)-N-(2-phenylethyl)ethanamide