tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate

Base Information

• Chemical Name: tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate
• CAS No.: 934987-46-9
• Molecular Formula: C₂₂H₂₆FN₃O₂
• Molecular Weight: 383.466
• Mol file: 934987-46-9.mol

Synonyms:tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate

Chemical Property of tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate

There total 5 articles about tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H24FN3O2 (1609651-47-9) → tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate (934987-46-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 2.5h;

DOI:10.1016/j.bmcl.2014.03.070

Reference yield:

3-bromo-2-methylaniline (55289-36-6) → tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate (934987-46-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 1 h / 20 °C

1.2: 0.42 h / -5 °C

2.1: tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 60 °C

3.1: hydrogen; palladium on activated charcoal / ethanol / 2.5 h / 20 °C

With hydrogenchloride; palladium on activated charcoal; hydrogen; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.03.070

Reference yield:

4-bromo-1-(fluorophenyl)-1H-indazole (934986-90-0) → tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate (934987-46-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 60 °C

2: hydrogen; palladium on activated charcoal / ethanol / 2.5 h / 20 °C

With palladium on activated charcoal; hydrogen; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.03.070

upstream raw materials:

C₂₂H₂₄FN₃O₂

3-bromo-2-methylaniline

4-bromo-1-(fluorophenyl)-1H-indazole

4-fluoroboronic acid

Downstream raw materials:

(1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylamine