tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate

Base Information

Chemical Name:tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate
CAS No.:934987-46-9
Molecular Formula:C₂₂H₂₆FN₃O₂
Molecular Weight:383.466
Hs Code.:

Synonyms:tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate

Chemical Property:

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Technology Process of tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate

There total 5 articles about tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609651-47-9
C₂₂H₂₄FN₃O₂

: 934987-46-9
tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 2.5h;
DOI:10.1016/j.bmcl.2014.03.070

Reference yield:

: 55289-36-6
3-bromo-2-methylaniline

: 934987-46-9
tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 1 h / 20 °C

1.2: 0.42 h / -5 °C

2.1: tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 60 °C

3.1: hydrogen; palladium on activated charcoal / ethanol / 2.5 h / 20 °C

With hydrogenchloride; palladium on activated charcoal; hydrogen; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.03.070

Reference yield:

: 934986-90-0
4-bromo-1-(fluorophenyl)-1H-indazole

: 934987-46-9
tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 60 °C

2: hydrogen; palladium on activated charcoal / ethanol / 2.5 h / 20 °C

With palladium on activated charcoal; hydrogen; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.03.070