1609651-47-9

Basic information

• Product Name: C₂₂H₂₄FN₃O₂
• CAS NO: 1609651-47-9
• Molecular Weight: 381.45
• Mol File: 1609651-47-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₄FN₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₄FN₃O₂(1609651-47-9)
• EPA Substance Registry System: C₂₂H₂₄FN₃O₂(1609651-47-9)

Safety Data

• Hazardous Substances Data: 1609651-47-9(Hazardous Substances Data)

Upstream product

• 934986-90-0 4-bromo-1-(fluorophenyl)-1H-indazole 
• 115378-33-1 (-)-tert-butyl [(1S)-1-methylprop-2-en-1-yl]carbamate 
• 55289-36-6 3-bromo-2-methylaniline 
• 1765-93-1 4-fluoroboronic acid 

Downstream Products

• 934987-46-9 tert-butyl (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylcarbamate 
• 934987-47-0 (1S)-3-[1-(4-fluorophenyl)-1H-indazol-4-yl]-1-methylpropylamine 

Relevant articles and documents

The discovery of potent and selective non-steroidal glucocorticoid receptor modulators, suitable for inhalation

We report the discovery of highly potent and selective non-steroidal glucocorticoid receptor modulators with PK properties suitable for inhalation. A high throughput screen of the AstraZeneca compound collection identified sulfonamide 3 as a potent non-steroidal glucocorticoid receptor ligand. Further optimization of this lead generated indazoles 30 and 48 that were progressed to characterization in in vivo models. X-ray crystallography was used to gain further insight into the binding mode of selected ligands.