9,14,N(17)-tri(tert-butoxycarbonyl)-5-(2-nitrophenylsulfonyl)-N(1)-[(cholest-5-en-3β-yl)oxycarbonyl]-1,17-diamino-5,9,14-triazaheptadecane

Base Information

Chemical Name:9,14,N(17)-tri(tert-butoxycarbonyl)-5-(2-nitrophenylsulfonyl)-N(1)-[(cholest-5-en-3β-yl)oxycarbonyl]-1,17-diamino-5,9,14-triazaheptadecane
CAS No.:1208116-73-7
Molecular Formula:C₆₃H₁₀₆N₆O₁₂S
Molecular Weight:1171.63
Hs Code.:

Synonyms:9,14,N(17)-tri(tert-butoxycarbonyl)-5-(2-nitrophenylsulfonyl)-N(1)-[(cholest-5-en-3β-yl)oxycarbonyl]-1,17-diamino-5,9,14-triazaheptadecane

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Chemical Property of 9,14,N(17)-tri(tert-butoxycarbonyl)-5-(2-nitrophenylsulfonyl)-N(1)-[(cholest-5-en-3β-yl)oxycarbonyl]-1,17-diamino-5,9,14-triazaheptadecane

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Technology Process of 9,14,N(17)-tri(tert-butoxycarbonyl)-5-(2-nitrophenylsulfonyl)-N(1)-[(cholest-5-en-3β-yl)oxycarbonyl]-1,17-diamino-5,9,14-triazaheptadecane

There total 7 articles about 9,14,N(17)-tri(tert-butoxycarbonyl)-5-(2-nitrophenylsulfonyl)-N(1)-[(cholest-5-en-3β-yl)oxycarbonyl]-1,17-diamino-5,9,14-triazaheptadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1131915-22-4
tert-butyl (4-((tert-butoxycarbonyl)(3-((tert-butoxycarbonyl)amino)propyl)amino)butyl)(3-(2-nitrophenylsulfonamido)propyl)carbamate

: (cholest-5-en-3β-yl) N-(4-bromobutyl)carbamate

: 1208116-73-7
9,14,N(17)-tri(tert-butoxycarbonyl)-5-(2-nitrophenylsulfonyl)-N(1)-[(cholest-5-en-3β-yl)oxycarbonyl]-1,17-diamino-5,9,14-triazaheptadecane

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1h;
DOI:10.1007/s11172-010-0071-x

Reference yield:

: 57-88-5
cholesterol

: 1208116-73-7
9,14,N(17)-tri(tert-butoxycarbonyl)-5-(2-nitrophenylsulfonyl)-N(1)-[(cholest-5-en-3β-yl)oxycarbonyl]-1,17-diamino-5,9,14-triazaheptadecane

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 1 h / 0 - 24 °C

2: triethylamine / dichloromethane / 16 h / Reflux

3: dichloromethane / 18 h / Reflux

4: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 - 24 °C

5: caesium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

With pyridine; carbon tetrabromide; caesium carbonate; triethylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s11172-010-0071-x

Reference yield:

: 114459-62-0
tri-Boc-spermine

: 1208116-73-7
9,14,N(17)-tri(tert-butoxycarbonyl)-5-(2-nitrophenylsulfonyl)-N(1)-[(cholest-5-en-3β-yl)oxycarbonyl]-1,17-diamino-5,9,14-triazaheptadecane

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 0 - 24 °C / Molecular sieve

2: caesium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

With caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s11172-010-0071-x