5-aminomethyl-4-(4-methoxy-phenyl)-6-methyl-pyridine-2-carboxylic acid (5-methyl-isoxazol-3-yl)-amide hydrochloride

Base Information

Chemical Name:5-aminomethyl-4-(4-methoxy-phenyl)-6-methyl-pyridine-2-carboxylic acid (5-methyl-isoxazol-3-yl)-amide hydrochloride
CAS No.:1287725-92-1
Molecular Formula:C₁₉H₂₀N₄O₃*ClH
Molecular Weight:388.854
Hs Code.:

Synonyms:5-aminomethyl-4-(4-methoxy-phenyl)-6-methyl-pyridine-2-carboxylic acid (5-methyl-isoxazol-3-yl)-amide hydrochloride

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Chemical Property of 5-aminomethyl-4-(4-methoxy-phenyl)-6-methyl-pyridine-2-carboxylic acid (5-methyl-isoxazol-3-yl)-amide hydrochloride

Chemical Property:

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Technology Process of 5-aminomethyl-4-(4-methoxy-phenyl)-6-methyl-pyridine-2-carboxylic acid (5-methyl-isoxazol-3-yl)-amide hydrochloride

There total 4 articles about 5-aminomethyl-4-(4-methoxy-phenyl)-6-methyl-pyridine-2-carboxylic acid (5-methyl-isoxazol-3-yl)-amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253518-51-2
[4-(4-Methoxy-phenyl)-2-methyl-6-(5-methyl-isoxazol-3-yl-carbamoyl)-pyridine-3-yl-methyl]-carbamic acid tert-butyl ester

: 1287725-92-1
5-aminomethyl-4-(4-methoxy-phenyl)-6-methyl-pyridine-2-carboxylic acid (5-methyl-isoxazol-3-yl)-amide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

: 1253518-31-8
5-cyano-4-(4-methoxyphenyl)-6-methylpyridine-2-carboxylic acid

: 1287725-92-1
5-aminomethyl-4-(4-methoxy-phenyl)-6-methyl-pyridine-2-carboxylic acid (5-methyl-isoxazol-3-yl)-amide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / acetic acid / 16 h / 60 °C / 760.05 Torr

2.1: 1,4-dioxane; water / 16 h / 20 °C

2.2: 3 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; water; acetic acid;

Reference yield:

: 17451-21-7,128935-12-6
(E)-4-(4-methoxy-phenyl)-2-oxo-3-butenoic acid

: 1287725-92-1
5-aminomethyl-4-(4-methoxy-phenyl)-6-methyl-pyridine-2-carboxylic acid (5-methyl-isoxazol-3-yl)-amide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / acetonitrile / 16 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / acetic acid / 16 h / 60 °C / 760.05 Torr

3.1: 1,4-dioxane; water / 16 h / 20 °C

3.2: 3 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; potassium tert-butylate; hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; water; acetic acid; acetonitrile;