3-Butenoic acid, 4-(4-methoxyphenyl)-2-oxo-

Base Information

• Chemical Name: 3-Butenoic acid, 4-(4-methoxyphenyl)-2-oxo-
• CAS No.: 17451-21-7
• Molecular Formula: C11H10O4
• Molecular Weight: 206.198
• Mol file: 17451-21-7.mol

Synonyms:

Chemical Property of 3-Butenoic acid, 4-(4-methoxyphenyl)-2-oxo-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Butenoic acid, 4-(4-methoxyphenyl)-2-oxo-

There total 11 articles about 3-Butenoic acid, 4-(4-methoxyphenyl)-2-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

C11H9O4(1-)*K(1+) (860190-31-4) → 4-(4-methoxyphenyl)-2-oxo-3-butenoic acid (17451-21-7)

Guidance literature:

With hydrogenchloride; In water; for 12h;

DOI:10.1002/ejoc.202100022

Reference yield:

Oxalacetic acid (328-42-7) + 4-methoxy-benzaldehyde (123-11-5) → 4-hydroxy-4-(4-methoxyphenyl)-2-ketobutanoic acid (1034123-68-6) + (E)-4-(4-methoxy-phenyl)-2-oxo-3-butenoic acid (17451-21-7,128935-12-6)

Guidance literature:

4-methoxy-benzaldehyde; With macrophomate synthase from Macrophoma commelinae; magnesium chloride; In acetonitrile; at 20 ℃; for 0.166667h; pH=7.0; aq. phosphate buffer; Enzymatic reaction;

Oxalacetic acid; In acetonitrile; for 7h; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1021/ja8017994

Reference yield:

4-methoxy-benzaldehyde (123-11-5) + 2-oxo-propionic acid (127-17-3) → 4-(4-methoxyphenyl)-2-oxo-3-butenoic acid (17451-21-7)

Guidance literature:

With sodium hydroxide;

upstream raw materials:

4-methoxy-benzaldehyde

2-oxo-propionic acid

hydrogenchloride

C₁₁H₉O₄^(1-)*K⁽¹⁺⁾

Downstream raw materials:

(E)-methyl 4-(4-methoxyphenyl)-2-oxobut-3-enoate

ethyl 2-oxo-4-(p-methoxyphenyl)but-3-enoate

2-hydroxy-4-(4-methoxyphenyl)butanoic acid

2-hydroxy-4-(4-methoxyphenyl)but-3-enoic acid