N-hydroxy-6-(3-hydroxy-4-(2-hydroxycarbamoylethyl)-2-isopentyl-phenoxy)hexanamide

Base Information

Chemical Name:N-hydroxy-6-(3-hydroxy-4-(2-hydroxycarbamoylethyl)-2-isopentyl-phenoxy)hexanamide
CAS No.:1335107-63-5
Molecular Formula:C₂₀H₃₂N₂O₆
Molecular Weight:396.484
Hs Code.:

Synonyms:N-hydroxy-6-(3-hydroxy-4-(2-hydroxycarbamoylethyl)-2-isopentyl-phenoxy)hexanamide

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Chemical Property of N-hydroxy-6-(3-hydroxy-4-(2-hydroxycarbamoylethyl)-2-isopentyl-phenoxy)hexanamide

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Technology Process of N-hydroxy-6-(3-hydroxy-4-(2-hydroxycarbamoylethyl)-2-isopentyl-phenoxy)hexanamide

There total 5 articles about N-hydroxy-6-(3-hydroxy-4-(2-hydroxycarbamoylethyl)-2-isopentyl-phenoxy)hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1335107-55-5
6-(3,4-dihydro-8-isopentyl-2-oxo-2H-chromen-7-yloxy)hexanoic acid

: 1335107-63-5
N-hydroxy-6-(3-hydroxy-4-(2-hydroxycarbamoylethyl)-2-isopentyl-phenoxy)hexanamide

Guidance literature:: 6-(3,4-dihydro-8-isopentyl-2-oxo-2H-chromen-7-yloxy)hexanoic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 20 ℃; for 1h;

With hydroxylamine hydrochloride; potassium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 3h;
DOI:10.1016/j.ejmech.2011.06.002

Reference yield:

: ethyl 6-(3,4-dihydro-8-isopentyl-2-oxo-2H-chromen-7-yloxy)hexanoate

: 1335107-63-5
N-hydroxy-6-(3-hydroxy-4-(2-hydroxycarbamoylethyl)-2-isopentyl-phenoxy)hexanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; lithium hydroxide / 2 h / 63 °C / Inert atmosphere

2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 20 °C

2.2: 3 h / 20 °C

With methanol; chloroformic acid ethyl ester; triethylamine; lithium hydroxide; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2011.06.002

Reference yield:

: 181303-71-9
8-isopentyl-7-methoxy-chroman-2-one

: 1335107-63-5
N-hydroxy-6-(3-hydroxy-4-(2-hydroxycarbamoylethyl)-2-isopentyl-phenoxy)hexanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

1.2: Cooling with ice

2.1: 18-crown-6 ether; tetra-(n-butyl)ammonium iodide; potassium carbonate / acetone / 2 h / 56 °C / Inert atmosphere

3.1: methanol; lithium hydroxide / 2 h / 63 °C / Inert atmosphere

4.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 20 °C

4.2: 3 h / 20 °C

With methanol; 18-crown-6 ether; chloroformic acid ethyl ester; boron tribromide; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1016/j.ejmech.2011.06.002