(2S,3R,4R,4'R,5R)-6,8-diaza-3,4-dihydroxy-2-(2',2'-dimethyl-1',3'-dioxolane-4'-yl)-1-oxa-8-N-phenyl-spiro[4.4]nonane-7,9-dione

Base Information

Chemical Name:(2S,3R,4R,4'R,5R)-6,8-diaza-3,4-dihydroxy-2-(2',2'-dimethyl-1',3'-dioxolane-4'-yl)-1-oxa-8-N-phenyl-spiro[4.4]nonane-7,9-dione
CAS No.:182369-08-0
Molecular Formula:C₁₇H₂₀N₂O₇
Molecular Weight:364.355
Hs Code.:

Synonyms:(2S,3R,4R,4'R,5R)-6,8-diaza-3,4-dihydroxy-2-(2',2'-dimethyl-1',3'-dioxolane-4'-yl)-1-oxa-8-N-phenyl-spiro[4.4]nonane-7,9-dione

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Chemical Property of (2S,3R,4R,4'R,5R)-6,8-diaza-3,4-dihydroxy-2-(2',2'-dimethyl-1',3'-dioxolane-4'-yl)-1-oxa-8-N-phenyl-spiro[4.4]nonane-7,9-dione

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Technology Process of (2S,3R,4R,4'R,5R)-6,8-diaza-3,4-dihydroxy-2-(2',2'-dimethyl-1',3'-dioxolane-4'-yl)-1-oxa-8-N-phenyl-spiro[4.4]nonane-7,9-dione

There total 7 articles about (2S,3R,4R,4'R,5R)-6,8-diaza-3,4-dihydroxy-2-(2',2'-dimethyl-1',3'-dioxolane-4'-yl)-1-oxa-8-N-phenyl-spiro[4.4]nonane-7,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 67-64-1
acetone

: 164905-95-7
(1'R,2R,3R,4R,5R)-6,8-diaza-3,4-dihydroxy-2-(1',2'-dihydroxyethyl)-1-oxa-8-N-phenyl-spiro<4.4>nonane-7,9-dione

: 182369-08-0
(2S,3R,4R,4'R,5R)-6,8-diaza-3,4-dihydroxy-2-(2',2'-dimethyl-1',3'-dioxolane-4'-yl)-1-oxa-8-N-phenyl-spiro[4.4]nonane-7,9-dione

Guidance literature:: With camphor-10-sulfonic acid; for 2.5h;
DOI:10.1016/0040-4020(96)00595-9

Reference yield: 13.0%

: 164905-93-5
(2R,3S,4R,4'R,5R)-6,8-diaza-3,4-di-tert-butyldimethylsilyloxy-2-(2',2'-dimethyl-1',3'-dioxolane-4'-yl)-1-oxa-8-N-phenyl-spiro<4.4>nonane-7,9-dione

: 182220-16-2
(3aR,5S,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-6-hydroxy-2-oxo-tetrahydro-furo[2,3-d]oxazole-3a-carboxylic acid phenylamide

: 182369-08-0
(2S,3R,4R,4'R,5R)-6,8-diaza-3,4-dihydroxy-2-(2',2'-dimethyl-1',3'-dioxolane-4'-yl)-1-oxa-8-N-phenyl-spiro[4.4]nonane-7,9-dione

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 21h;
DOI:10.1016/0040-4020(96)00595-9

Reference yield:

: 103-71-9
phenyl isocyanate

: 182369-08-0
(2S,3R,4R,4'R,5R)-6,8-diaza-3,4-dihydroxy-2-(2',2'-dimethyl-1',3'-dioxolane-4'-yl)-1-oxa-8-N-phenyl-spiro[4.4]nonane-7,9-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 17 percent / tetrahydrofuran / 14 h

2: 88 percent / potassium tert-butoxide / dimethylformamide / 1 h

3: 75 percent / aq. trifluoroacetic acid / dioxane / 26 h

4: 76 percent / camphor sulfonic acid / 2.5 h

With camphor-10-sulfonic acid; potassium tert-butylate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(96)00595-9